Harmful effects of pyrethroid ester insecticide on the male reproductive system mainly through affecting testicular function and inflammatory markers  

作　　者：Ha ABDEL MAKSOUD Mk MAHFOUZ Mi SOLIMAN Mohamed G ELHARRIF M ABBASS Ma EL-BADRY 

机构地区：[1]Department of Biochemistry,Benha University,Benha,Egypt [2]Department of Basic Medical Sciences,Shaqra University,Shaqraa,Saudi Arabia

出　　处：《BIOCELL》2020年第1期111-115,共5页生物细胞（英文）

摘　　要：Pyrethroid esters are widely used as insecticides worldwide. In this study, we aimed to evaluate the harmful effect of deltamethrin on the male reproductive system through the assessment of reproductive hormones, inflammatorymarkers, and testicular function. To achieve our aim, eighty male 7-9-week-old, Wistar rats were taken, weighed, and divided into four experimental groups. The first group was kept as a control group, and the other three groups were given deltamethrin orally at different concentrations (0.87, 8.7, and 17.4 mg/kg body weight) for nine weeks. The resultsindicated that deltamethrin administration associated with a significant decrease in reproductive hormones, especially FSH, LH, and significant elevation in the interleukin 2 (IL2), interleukin 6 (IL6), histamine, and cortisol levels. Also, thesignificance of inhibition of sperm motility and viability, decreased testis weights, sperm count, and fructose in semen were noted. These findings clarify the harmful effect of deltamethrin on the male reproductive system by producing a significant alteration in reproductive hormones, inflammatory markers as well as testicular function.

关 键 词：DELTAMETHRIN Reproductive hormones Inflammatory markers 

分 类 号：O62[理学—有机化学]