普萘洛尔治疗婴幼儿声门下血管瘤的疗效分析  

Treatment for infantile subglottic hemangioma with oral propranolol

作　　者：陈伟[1] 陈佳瑞[1] 陈淑梅[1] 王颖[1] 赵利敏[1] 徐宏鸣 李晓艳[1] CHEN Wei;CHEN Jiarui;CHEN Shumei;WANG Ying;ZHAO Limin;XU Hongming;LI Xiaoyan(Department of Otolaryngology Head and Neck Surgery,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai,200062,China)

机构地区：[1]上海市儿童医院上海交通大学附属儿童医院耳鼻咽喉头颈外科,上海200062

出　　处：《临床耳鼻咽喉头颈外科杂志》2022年第1期55-58,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨婴幼儿声门下血管瘤(SGH)的临床特征,观察普萘洛尔治疗SGH的安全性和有效性。方法:回顾性分析2015年11月—2020年3月于上海市儿童医院确诊为SGH并使用普萘洛尔治疗的13例患儿的基本资料并进行随访。13例患儿均行纤维喉镜检查,10例行颈部增强CT检查。2例全身麻醉下行喉探查术。心电监测下给药,起始剂量1 mg/(kg·d),分3次口服,如无不良反应,第2天调整剂量为1.5 mg/(kg·d),并维持该剂量(不随体重增加而增加)直至疗程结束。结果:治疗结束年龄9~38个月,仅2例超过2岁,平均(19.3±7.7)个月;治疗时间6~21.3个月,平均(13.3±4.9)个月;随访21~71个月,平均(46.8±14.9)个月。13例患儿全部治愈。结论:2岁以内的婴幼儿喉喘鸣经常规治疗效果不佳或者病情反复,应考虑SGH的可能。纤维喉镜检查并结合颈部增强CT值得推荐。口服普萘洛尔治疗SGH安全有效,建议临床用药至19月龄以上以减少复发,2岁龄可能是停药的最佳时机。Objective: To investigate the clinical characteristics of infantile subglottic hemangioma(SGH), and to observe the safety and efficacy of propranolol in the treatment of SGH. Methods: The data of 13 children diagnosed with SGH and treated with propranolol in Shanghai Children’s Hospital from November 2015 to March 2020 were retrospectively analyzed and followed up. All 13 cases underwent laryngoscopy and 10 cases underwentcontrastenhanced CT. Laryngeal exploration under general anesthesia was performed in 2 cases. Propranolol was started at 1 mg/(kg·d) divided into 3 doses. Heart rate and blood pressure were monitored during treatment. If no side effects were observed, then the dose was increased to 1.5 mg/(kg·d) on the second day. It was suggested to maintain this starting dose at diagnosis(1.5 mg/kg body weight), and not increase the number of milligrams as the child gained weight. Results: The age at therapy termination ranged from 9 months to 38 months, only 2 cases beyond 2 years old, with an average of(19.3±7.7) months. The treatmentduration ranged from 6 to 21.3 months, with an average of(13.3±4.9) months. The follow-up time ranged from 21 to 71 months, with an average of(46.8±14.9) months. All 13 cases were cured. Conclusion: Infants under 2 years old with stridor have poor effect or repeated condition after routine treatment, SGH should be considered at this moment. Laryngoscopy combined with contrastenhanced CT is recommended. Oral propranolol is safe and effective in the treatment of SGH. It is suggested to oral propranololbeyond 19 months old to reduce recurrence, furthermore, 2 years old may be the best time for therapy termination.

关 键 词：普萘洛尔 婴幼儿 声门下血管瘤 

分 类 号：R767.4[医药卫生—耳鼻咽喉科]