Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones  

作　　者：Faqian He Guosong Shen Xiaoyu Yang 

机构地区：[1]School of Physical Science and Technology,ShanghaiTech University,Shanghai 201210,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2022年第1期15-20,共6页中国化学（英文版）

基　　金：NSFC(Grant No.22171186);ShanghaiTech University start-up funding for financial support;the support from Analytical Instrumentation Center(contract no.SPST-AIC10112914),SPST,ShanghaiTech University,and Dr.Na Yu for the X-ray crystallographic analysis.

摘　　要：An efficient method for asymmetric synthesis of acyclic α-tertiary amine derivatives has been achieved through enantioselective aminations of α-branched ynones with azodicarboxylates enabled by chiral phosphoric acid catalysis.Moreover,kinetic resolution of racemic starting material was realized under these conditions,which gave access to valuable enantioenriched α-substituted ketones.

关 键 词：Asymmetric catalysis Amination Kinetic resolution Chiral phosphoric acids α-Branched ynones 

分 类 号：O62[理学—有机化学]