New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata  

作　　者：Na Lin Heng Li Jian-Rong Wang Wei Tang Ming-Yue Zheng Hong Wang Cheng-Shi Jiang Yue-Wei Guo 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China [2]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zu Chong Zhi Road,Zhangjiang Hi-Tech Park,Shanghai 201203,China [3]Bohai rim Advanced Research Institute for Drug Discovery,Binhai East Road,198#,High-tech Zone,Yantai,Shandong 264000,China [4]School of Biological Science and Technology,University of Jinan,Jinan,Shandong 250022,China

出　　处：《Chinese Journal of Chemistry》2022年第1期28-38,共11页中国化学（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2018YFC0310903);the Natural Science Foundation of China(No.81991521);the SKLDR/SIMM Project(SIMM2103ZZ-06).

摘　　要：In the present study,nine new cembrane-type diterpenoids,namely ximaonanolobatins A—I(1—9),together with six related known analogs(10—15)and four known tetraprenylated alkaloids malonganenones D,E,H,and K(16—19)were isolated from the soft coral Sinularia nanolobata collected off the Ximao Island in the South China Sea.The structures of 1—9 were robustly established by a combination of detailed spectroscopic analyses,chemical reactions,quantum mechanical(QM)-NMR methods,biogenetic consideration,and the comparison with those literature data.The absolute configuration of 1 was confirmed by X-ray diffraction analysis,and the absolute configuration of 2 was determined by QM-NMR calculations and chemical transformation.In addition,the absolute configuration of 3 was determined using the modified Mosher's method.All these isolates were evaluated for their anti-inflammatory and anti-tumor activities.The results showed that only compound 15 exhibited potential anti-inflammatory effect against LPS-induced TNF-αrelease in RAW264.7 macrophages with an IC50 value of 12.6μmol/L.

关 键 词：Sinularia nanolobata Cembranoids X-ray diffraction Con figuration determination Natural products 

分 类 号：O62[理学—有机化学]