Au(Ⅰ)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole, Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives  

作　　者：Jiayue Fu Bingbing Li Xiugui Wang Qida Liang Xiaoshi Peng Lu Yang Tao Wan Xinxiu Wang Bin Lin Maosheng Cheng Yongxiang Liu 

机构地区：[1]Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University),Ministry of Education,Shenyang,Liaoning 110016,China [2]Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China [3]Institute of Drug Research in Medicine Capital of China,Benxi,Liaoning 117000,China [4]Liaoning Kangboshi Pharmaceutical Co.,LTD,Anshan,Liaoning 114100,China

出　　处：《Chinese Journal of Chemistry》2022年第1期46-52,共7页中国化学（英文版）

基　　金：the financial support of the National Natural Science Foundation of China(Grants 21977073);the Liao-ning BaiQianWan Talents Program;Liaoning Revitalization Tale nts Program;the program for the innoyative research team of the Ministry of Education;the program for the Liaoning innovative research team in university.

摘　　要：A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.

关 键 词：Gold Homogeneous catalysis 6-endo-dig Cyclization Heterocycles Divergent synthesis 

分 类 号：O626[理学—有机化学]