Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols  

作　　者：Zhao-Nan Cai Xiang-Xuan Feng Yuecheng Zhang Cong-Cong Lu Ya-Ping Han Jiquan Zhao 

机构地区：[1]School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130,China

出　　处：《Chinese Journal of Chemistry》2022年第1期71-78,共8页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21776056);the Natural Foundation of Hebei Province(CN)(Nos.B2020202010,ZD2021026).

摘　　要：A novel,green,and transition-metal-free protocol for the facile modification of quinoline and isoquinoline derivatives is introduced,starting from readily available and environmentally benign quinoline and isoquinoline N-oxides with propargylic alcohols in the presence of Na_(2)S_(2)O_(8) or K_(2)S_(2)O_(8) at 100℃.The one-pot transformation features the advantages of good functional group compatibility,short reaction time,operational simplicity,and highly efficient reaction system.This protocol,which produces water as the only byproduct,provides efficient and atom-economical access to a class of fascinating quinoline and isoquinoline products in satisfactory yields.The method is effective on the gram scale,thus highlighting the inherent practicality of this methodology.

关 键 词：Synthetic methods Alcohols Nitrogen heterocycles Transition-metal-free Solvent-free 

分 类 号：O62[理学—有机化学]