Nrf2激活剂及其抗紫外线所致皮肤急性光损伤和慢性光老化的研究进展  

Research progress of Nrf2 activators and their anti-ultraviolet induced acute photodamage and chronic photoaging of skin

作　　者：徐霞[1] 李振洁[1] Xu Xia;Li Zhenjie(Department of Dermatology,Guangzhou Institute of Dermatology Prevention and Treatment,Guangzhou 510095,China)

机构地区：[1]广州市皮肤病防治所皮肤科,广州510095

出　　处：《国际医药卫生导报》2022年第3期303-307,共5页International Medicine and Health Guidance News

基　　金：广东省医学科学技术研究基金项目(A2019180);广东省中医药局科研项目(20191253);广州市卫生健康科技项目(20191A010052)。

摘　　要：紫外线(ultraviolet,UV)照射产生活性氧(reactive oxygen species,ROS)及自由基,与皮肤急性光损伤和慢性光老化发生密切相关。核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)是调节抗氧化应激反应的重要转录因子,Nrf2转录活性发挥着协调相解毒酶、炎症信号转导、DNA修复和抗氧化反应的作用。Nrf2激活剂具有激活Nrf2通路、影响丝裂原激活蛋白激酶(mitogen activated protein kinase,MAPK)/激活蛋白-1(Activator protein 1,AP-1)信号系统和增加皮肤屏障蛋白表达等作用。Ultraviolet(UV)irradiation produces reactive oxygen species(ROS)and free radicals which are closely related to acute photodamage and chronic photoaging of skin.Nuclear factor erythroid 2-related factor 2(Nrf2)is an important transcription factor regulating antioxidant stress response.Nrf2 transcriptional activity plays a role in coordinating phaseⅡdetoxification enzyme,inflammatory signal transduction,DNA repair,and antioxidant response.Nrf2 activator can activate Nrf2 pathway,affect mitogen activated protein kinase(MAPK)/activator protein 1(AP-1)signaling system,and increase skin barrier protein expression.

关 键 词：NRF2 氧化应激 Nrf2激活剂 光损伤 

分 类 号：R751[医药卫生—皮肤病学与性病学]