合成氧杂环化合物的双环化反应研究  

Study on the Bicyclization of Synthetic Oxygen Heterocyclic Compounds

作　　者：范威 FAN Wei(Office of Research Affairs,Chuzhou City Vocation College,Chuzhou,239000,China)

机构地区：[1]滁州城市职业学院科研处,安徽滁州239000

出　　处：《安阳工学院学报》2022年第2期32-36,共5页Journal of Anyang Institute of Technology

基　　金：安徽省教育厅自然科学项目(KJ2020A1003);滁州城市职业学院院级横向课题(2021hxkt01)。

摘　　要：以呋喃和吡喃为代表的氧杂环骨架存在于Puupehedione、Peniphenone A、Virgatoldes B等活性分子中,具有抗癌、抗溃疡、抗氧化等多样的生物活性。通过分子内和分子间双环化反应来构建氧杂环骨架得到了充分研究。归纳总结已有文献的优缺点,将为探寻新的氧杂环合成方法指明方向。The oxygen heterocyclic skeleton represented by furan and pyran exists in active molecules such as Puupehedione,Peniphenone A and Virgatoldes B,which has various biological activities such as anti-cancer,anti-ulcer,and anti-oxidation.The construction of oxygen heterocyclic skeleton by intra-and intermolecular bicyclization reactions has been fully studied.Summarizing the advantages and disadvantages of the existing literatures will point out the direction for exploring new synthetic methods of oxygen heterocycles.

关 键 词：呋喃 吡喃 氧杂环 

分 类 号：O626[理学—有机化学]