毒性弥漫性甲状腺肿病患者^(131)I治疗前后外周血Th1/Th2细胞及Fas/FasL表达分析  

Expressions of peripheral blood Th1/Th2 and Fas/FasL in patients with toxic diffuse goiter before and after ^(131)I treatment

作　　者：蔡丽娟 任妹[1] 刘剑荣 潘幸 CAI Lijuan;REN Mei;LIU Jianrong;PAN Xing(Department of Laboratory Medicine,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China;Department of Endocrinology,Pingxiang People′s Hospital,Jiangxi Province,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市人民医院检验科,江西萍乡337000 [2]江西省萍乡市人民医院内分泌科,江西萍乡337000

出　　处：《中国当代医药》2022年第5期59-61,共3页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20164048)。

摘　　要：目的分析毒性弥漫性甲状腺肿(Graves病)患者^(131)I治疗前后外周血Th1/Th2及Fas/FasL的表达情况。方法选取2016年1月至12月在萍乡市人民医院确诊的60例Graves病患者为观察组,并选取同期60例健康者作为对照组。观察组患者均为首次行^(131)I治疗,经治疗随访12个月后,根据疗效分为缓解组(54例)和复发组(6例)。比较患者治疗前后的外周血Th1/Th2偏移情况以及Fas/FasL的表达水平变化。结果观察组的白细胞介素-12(IL-12)、白细胞介素-10(IL-10)、IL-12/IL-10高于对照组,缓解组的IL-10高于对照组,复发组的IL-12、IL-10高于对照组,差异有统计学意义(P<0.05)。缓解组的IL-12、IL-12/IL-10低于观察组及复发组,差异有统计学意义(P<0.05),复发组与观察组的IL-12、IL-10、IL-12/IL-10比较,差异无统计学意义(P>0.05)。观察组的Fas、FasL高于对照组,缓解组、复发组的Fas高于对照组,差异有统计学意义(P<0.05)。缓解组的Fas低于观察组及复发组,差异有统计学意义(P<0.05)。复发组与观察组的Fas、FasL比较,差异无统计学意义(P>0.05)。结论治疗后,复发的Graves病患者的免疫反应更趋于Th1,Fas水平随着Graves病的发展升高,提示可根据患者的临床表现联合辅助T细胞的趋向以及Fas检测结果评价其治疗效果。Objective To analyze the expression of Th1/Th2 and Fas/FasL in peripheral blood of patients with toxic diffuse goiter(Graves disease)before and after ^(131)I treatment.Methods Sixty Graves patients diagnosed in Pingxiang People′s Hospital from January to December 2016 were selected as the observation group,and 60 healthy subjects were selected as the control group during the same period.All patients in the observation group received ^(131)I treatment for the first time,and were divided into remission group(54 cases)and recurrence group(6 cases)according to the curative effect after 12 months of follow-up.The changes of Th1/Th2 migration and Fas/FasL expression in peripheral blood of patients before and after treatment were compared.Results Interleukin-12(IL-12),interleukin-10(IL-10),IL-12/IL-10 in the observation group were higher than those in the control group,IL-10 in remission group was higher than control group,IL-12、IL-10 in recurrence group were higher than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in IL-12,IL-10,IL-12/IL-10 between the recurrence group and the observation group(P>0.05).Fas and FasL in the observation group were higher than those in the control group,Fas in remission group and recurrence group was higher than that in control group,the differences were statistically significant(P<0.05).Fas in remission group was lower than that in observation group and recurrence group,the difference was statistically significant(P<0.05).There were no significant differences in Fas and FasL between the recurrence group and the observation group(P>0.05).Conclusion After treatment,the immune response of recurrent Graves patients tended to be more Th1,and Fas level increased with the development of Graves disease.It is indicated that curative effect can be assessed according to clinical manifestations combined with the trend of helper T cells and test results of Fas.

关 键 词：毒性弥漫性甲状腺肿 放射性^(131)I治疗 TH1/TH2 FAS/FASL 

分 类 号：R581[医药卫生—内分泌]