壳聚糖及其衍生物递送miRNA/siRNA的研究进展  

Research Progress in miRNA/siRNA Delivery by Chitosan and Its Derivatives

作　　者：孙玥 丁威豪 黎白钰[1] 王晓强[1] Sun Yue;Ding Weihao;Li Baiyu;Wang Xiaoqiang(School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou,730070)

机构地区：[1]兰州交通大学化学与生物工程学院,兰州730070

出　　处：《化学通报》2022年第2期186-191,共6页Chemistry

基　　金：兰州交通大学天佑创新团队项目(TY202004);兰州交通大学-天津大学联合创新基金项目(2021059)资助。

摘　　要：微小RNA(microRNA,miRNA)和短链干扰RNA(small interfering RNA,siRNA)是两类具有调节基因表达功能的内源性非编码性小RNA分子。它们已成为多种疾病的潜在治疗药物,逐渐被应用于基因治疗中,而将小RNA应用于基因治疗亟需一种安全高效的递送载体。壳聚糖及其衍生物作为一种可降解、低细胞毒性的递送载体,在递送小RNA方面具有极大的潜力。本文介绍了近年来壳聚糖及其衍生物纳米微粒作为递送miRNA和siRNA载体的制备及应用的相关进展。MicroRNA(miRNA)and small interfering RNA(siRNA)are small,noncoding endogenous RNA regulatory molecules that control gene expression.They have become a potential therapeutic target for a variety of diseases and are gradually used in gene therapy.The application of small RNA in gene therapy needs a safe and efficient delivery carrier.Chitosan and its derivatives,as a degradable and low-cytotoxic delivery vehicle,have great potential in the delivery of small RNA.In this review,the recent progress in the preparation and application of chitosan as miRNA and siRNA delivery carriers is reviewed.

关 键 词：壳聚糖及其衍生物 MIRNA SIRNA 递送载体 

分 类 号：R318[医药卫生—生物医学工程]