卵泡刺激素受体信号调节及相关生物学功能研究进展  

Research progress in follicle-stimulating hormone receptor signaling regulation and biological functions

作　　者：高玲芸 王文君[1] Gao Lingyun;Wang Wenjun(Obstetrics and Gynecology Hospital of Fudan University,Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院,上海市女性生殖内分泌相关疾病重点实验室,上海200011

出　　处：《中华生殖与避孕杂志》2022年第1期91-95,共5页Chinese Journal of Reproduction and Contraception

摘　　要：卵泡刺激素(follicle-stimulating hormone,FSH)是调节卵巢颗粒细胞和睾丸支持细胞功能的重要激素,其作用由卵泡刺激素受体(follicle-stimulating hormone receptor,FSHR)介导。FSHR下游信号通路包括G蛋白介导的下游信号、辅助信号分子参与激活的下游信号、与其他胞质膜信号分子相互作用产生的信号等。近年来随着科研技术的发展,FSHR信号的精细调节方式被进一步揭示,组学技术的广泛应用也为信号调控机制的研究提供了更多的方法和可能性。此外,大量最新研究显示非性腺组织中广泛分布具有生物学活性的FSHR,可能与绝经后相关并发症如骨质疏松和代谢综合征有关,肿瘤组织、生殖系统非性腺组织以及胎儿组织等部位的FSHR可能也具有促血管生成等生物学功能,提示FSH可能在多系统生理病理过程中均发挥作用,这为FSHR的相关研究开展提供了全新的视角,本文就此进行综述。Follicle-stimulating hormone(FSH),functioning through binding to follicle-stimulating hormone receptors(FSHR),is the key hormone regulating biological functions of granulosa cells and Sertoli cells.Signals intermediated by FSHR mainly transduced by G protein,adaptor proteins and other membrane receptors.With rapid development of analytical chemistry and multi-omics technologies,detailed regulation modle of FSHR signaling have been unveiled in recent years.From a macroscopic view,recent researches have indicated the existence of FSHR in various extra-gonadal tissues,which play biological functions in various diseases including postmenopausal related diseases,chronic renal insufficiency,and lipid metabolic disorder.FSHR in other extra-gonadal tissues such as malignant tumor and reproductive tissue may also exert functional effects like angiogenesis.These evidences suggest a systematic role of FSHR beyond gonadal tissue and provide a brand-new perspective to view this classical G protein-coupled receptor.Current work reviews recent research progress in FSH/FSHR signaling regulation and new biological functions regarding FSHR expression beyond gonadal tissue.

关 键 词：卵泡刺激素受体 颗粒细胞 信号通路 蛋白激酶A G蛋白偶联受体 

分 类 号：R341[医药卫生—基础医学]