快速界面聚合包覆毫米级海藻酸钙水润珠  

Rapid Coating of Millimeter-Scale Calcium Alginate Liquid Core Capsules with Interfacial Polymerization

作　　者：肜霖[1] 穆晓庆 赵瑾朝[3] 黄乐平 叶明樵[1] 王娜[1] Lin Rong;Xiaoqing Mu;Jinchao Zhao;Leping Huang;Mingqiao Ye;Na Wang(China Tobacco Hubei Industrial CO.,LTD,Wuhan 430040,China;School of Material Science and Engineering,Wuhan Textile University,Wuhan 430200,China;Hubei Key Laboratory of Biomass Fibers and Eco-Dyeing&Finishing,Wuhan Textile University,Wuhan 430200,China)

机构地区：[1]湖北中烟工业有限责任公司,湖北武汉430040 [2]武汉纺织大学材料科学与工程学院,湖北武汉430200 [3]武汉纺织大学生物质纤维与生态染整湖北省重点实验室,湖北武汉430200

出　　处：《高分子材料科学与工程》2021年第11期158-163,172,共7页Polymer Materials Science & Engineering

摘　　要：通过界面聚合法,采用非溶剂硅油分散毫米级海藻酸钙载水胶囊(水润珠),利用水润珠表面微量水分引发氰基丙烯酸乙酯(ECA)原位聚合,形成聚氰基丙烯酸乙酯包覆水润珠(PECA@水润珠)。研究了ECA的添加量对水润珠结构、形貌、缓释性能和热稳定性的影响。结果表明,水润珠表面形成白色聚合物包覆层,随着ECA添加量的增大,水润珠粒径增大,包覆层厚度增加,失重率降低,PECA@水润珠囊壁的阻隔性能和热稳定性增强。与未包覆的水润珠相比,当ECA的添加量为2mL时,水润珠在24h的失重率降低了57.89%,有效延缓了芯层水分的扩散。该方法全过程绿色无毒、反应迅速且温和,有望实现大粒径水凝胶胶囊表面的均匀包覆及工业化生产,在生物医药领域具有重要的应用价值。The ethylα-cyanoacrylate(ECA)was in-situ polymerized into poly(ethylα-cyanoacrylate)(PECA)successfully on the surface of the millimeter-scale calcium alginate liquid core capsules(CaSA-caps),which was triggered by water in CaSA-caps dispersed in silicone oil.The effects of ECA amount on the structure,morphology,controlled release property and thermal stability of CaSA-caps coated with PECA(PECA@CaSA-caps)were investigated.The results show that white PECA coating was formed on the surface of CaSA-caps.With the increase of ECA amount,the diameter of PECA@CaSA-caps and the thickness of coating both increase;while the mass loss ratio of PECA@CaSA-caps decreases.The barrier property and thermal stability of the capsule wall of PECA@CaSA-caps are enhanced.Compared with CaSA-caps,the mass loss ratio of PECA@CaSA-caps is decreased by 57.89%in 24 h when the ECA amount is 2 mL/g,and the PECA coating can effectively prevent the diffusion of water.In general,the preparation process is green,non-toxic and rapid under mild reaction conditions.Industrialized production of PECA@CaSA-caps can be achieved,indicating that the large-size hydrogel capsules can be modified with uniform coating,which has important values in the field of biological medicine.

关 键 词：毫米级海藻酸钙胶囊 氰基丙烯酸乙酯 界面聚合 缓释性能 

分 类 号：R318.08[医药卫生—生物医学工程]