脂质代谢紊乱与足细胞损伤研究进展  

Research progress of lipid metabolism disorders and podocyte injury

作　　者：李莉 冯科 巩永凤 LI Li;FENG Ke;GONG Yongfeng(Department of Physiology,School of Basic Medicine,Binzhou Medical University,Yantai 264003,Shandong,P.R.China)

机构地区：[1]滨州医学院基础医学院生理学教研室,山东烟台264003

出　　处：《滨州医学院学报》2022年第1期69-72,76,共5页Journal of Binzhou Medical University

基　　金：国家自然科学基金(81670620,81870485)。

摘　　要：脂质肾毒性被认为是慢性肾脏疾病(CKD)的病因之一。脂质代谢紊乱引起脂质异位沉积于肾脏足细胞中,参与CKD发生和进展的病理生理过程,并导致足细胞的胰岛素信号异常、线粒体功能障碍、内质网应激和凋亡。因此,纠正肾脏脂质代谢紊乱是CKD的一个重要治疗目标。本文回顾了脂质肾毒性的研究进展以便更好地理解血脂异常在CKD发病中起到的作用。The toxicity of lipid accumulation(lipotoxicity)in the kidney represents a cause of chronic kidney diseases(CKD).Different types of lipid metabolism disorders can lead to ectopic lipid deposition in the kidney and podocytes,participating in the pathophysiological processes of CKD occurrence and progression.It also leads to abnormal cellular insulin signaling,mitochondrial dysfunction,endoplasmic reticulum stress and apoptosis.Therefore,controlling lipid metabolism disorder in the kidney is a very important therapeutic goal.This article will review the research advances in lipid nephrotoxicity to better understand the role of dyslipidemia in CKD.

关 键 词：足细胞 脂质肾毒性 代谢紊乱 蛋白尿 

分 类 号：R334.1[医药卫生—人体生理学]