血清基质金属蛋白酶抑制因子-1、半乳糖凝集素-3水平与未足月胎膜早破患者发生绒毛膜羊膜炎的关系  

Relationship Between Serum Tissue Inhibitor of Metalloproteinase-1 and Galectin-3 Levels and Chorioamnionitis in Patients with Preterm Premature Rupture of Membranes

作　　者：袁路路 赵晓丹 YUAN Lulu;ZHAO Xiaodan(Department of Obstetrics,New District Hospital of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院新区医院产科,河南洛阳471000

出　　处：《河南医学研究》2022年第4期648-651,共4页Henan Medical Research

摘　　要：目的观察血清基质金属蛋白酶抑制因子-1(TIMP-1)、半乳糖凝集素-(Gal-3)在未足月胎膜早破(PPROM)患者中的表达,并分析二者水平对PPROM患者绒毛膜羊膜炎发生的影响。方法选取2019年9月至2021年5月河南科技大学第一附属医院新区医院接收的92例PPROM患者作为研究对象。依据病理检查结果判定PPROM患者绒毛膜羊膜炎发生情况并进行分组,设计患者基线资料填写表,询问并记录研究所需资料,检测患者确诊时血清TIMP-1、Gal-3水平,并分析血清TIMP-1、Gal-3水平对PPROM患者绒毛膜羊膜炎发生的影响。结果92例PPROM患者分娩后经病理检查,发生绒毛膜羊膜炎48例,占52.17%(48/92);发生组确诊时血清TIMP-1水平低于未发生组,确诊时血清Gal-3水平高于未发生组,差异有统计学意义(P<0.05);组间其他资料比较,差异无统计学意义(P>0.05);经logistic回归分析,结果显示,血清TIMP-1水平过表达是PPROM患者发生绒毛膜羊膜炎的保护因素(OR<1,P<0.05),血清Gal-3水平过表达是PPROM患者绒毛膜羊膜炎发生的危险因素(OR>1,P<0.05)。结论血清TIMP-1、Gal-3水平对PPROM患者绒毛膜羊膜炎发生具有一定影响,且血清TIMP-1水平低表达、Gal-3水平过表达提示PPROM患者绒毛膜羊膜炎发生风险较高。Objective To observe the expression of serum tissue inhibitor of metalloproteinase-1(TIMP-1)and galectin-3(Gal-3)levels in patients with preterm premature rupture of membranes(PPROM),and to analyze the effect of both levels on chorioamnionitis in patients with PPROM.Methods A total of 92 patients with PPROM who were admitted to the New District Hospital of the First Affiliated Hospital of Henan University of Science and Technology from September 2019 to May 2021 were selected as the research subjects.According to the results of pathological examination,the occurrence of chorioamnionitis in PPROM patients was determined and divided into groups.The baseline data filling form of patients were designed,and the information required for the study were asked and recorded.The levels of serum TIMP-1 and Gal-3 of patients at diagnosis were tested,and the effect of serum TIMP-1 and Gal-3 levels on chorioamnionitis in patients with PPROM was analyzed.Results After delivery,48 of 92 PPROM patients developed chorioamnionitis by pathological examination,accounting for 52.17%(48/92).The level of serum TIMP-1 at diagnosis in the occurrence group was lower than that in the non-occurrence group,and the level of serum Gal-3 at diagnosis was higher than that in the non-occurrence group(P<0.05).There were no statistical significant differences in other data between groups(P>0.05).The results of logistic regression analysis showed that,overexpression of serum TIMP-1 level was a protective factor for chorioamnionitis in PPROM patients(OR<1,P<0.05),and the overexpression of serum Gal-3 level was a risk factor for chorioamnionitis in patients with PPROM(OR>1,P<0.05).Conclusion The levels of serum TIMP-1 and Gal-3 have certain effect on the occurrence of chorioamnionitis in patients with PPROM,and the low expression of serum TIMP-1 and overexpression of Gal-3 suggest that patients with PPROM have a higher risk of chorioamnionitis.

关 键 词：未足月胎膜早破 绒毛膜羊膜炎 基质金属蛋白酶抑制因子-1 半乳糖凝集素-3 

分 类 号：R714.259[医药卫生—妇产科学]