白术中新桉叶烷倍半萜类成分及其SREBPs抑制活性  

New eudesmane sesquiterpenoids from Atractylodis Macrocephalae Rhizoma and their inhibitory activities against SREBPs

作　　者：许睿珠 赵璇[2] 杜月月 许梦莎 刘新光[1] 谢治深 高松 徐江雁[1] 王潘 XU Rui-zhu;ZHAO Xuan;DU Yue-yue;XU Meng-sha;LIU Xin-guang;XIE Zhi-shen;GAO Song;XU Jiang-yan;WANG Pan(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Technological Innovation Center for Solid Preparation of Traditional Chinese Medicine,Zhongjing Wanxi Pharmaceutical Co.,Ltd.,Nanyang 474500,China)

机构地区：[1]河南中医药大学中医药科学院,河南郑州450046 [2]河南中医药大学药学院,河南郑州450046 [3]仲景宛西制药股份有限公司河南省中药固体制剂技术创新中心,河南南阳474500

出　　处：《中国中药杂志》2022年第2期428-432,共5页China Journal of Chinese Materia Medica

基　　金：中国博士后科学基金项目(2021M693704,2018M642761);河南省科技攻关项目(202102310183,202102310173);河南省中医药科学研究专项课题-重大项目(2018ZYZD12);大学生创新创业训练计划项目(S202010471046)。

摘　　要：采用正相硅胶、Sephadex LH-20、ODS、HPLC等色谱手段,对中药白术的化学成分进行研究,从白术干燥根茎95%乙醇提取物中分离得到3个倍半萜类化合物,并根据波谱数据和理化性质对其结构进行鉴定,分别鉴定为2个桉叶烷倍半萜(7Z)-8β,13-diacetoxy-eudesma-4(15),7(11)-diene(1)、7-oxo-7,8-secoeudesma-4(15),11-dien-8-oic acid(2)及1个愈创木烷倍半萜guai-10(14)-en-11-ol(3)。其中化合物1和2为新化合物,化合物3为首次从菊科中分离得到。化合物1~3对SREBPs均具有一定的抑制作用。Three sesquiterpenoids were isolated and purified from the 95%ethanol extract of Atractylodis Macrocephalae Rhizoma by column chromatography on silica gel,Sephadex LH-20,ODS,and high-performance liquid chromatography(HPLC).Their chemical structures were identified on the basis of spectroscopic analysis and physiochemical properties as(7Z)-8β,13-diacetoxy-eudesma-4(15),7(11)-diene(1),7-oxo-7,8-secoeudesma-4(15),11-dien-8-oic acid(2),and guai-10(14)-en-11-ol(3).Compounds 1 and 2 are new compounds and compound 3 was obtained from Compositae family for the first time.Compounds 1,2,and 3 showed weak inhibitory activities against sterol regulatory element-binding proteins(SREBPs).

关 键 词：白术 化学成分 倍半萜 SREBPs抑制剂 

分 类 号：R284.1[医药卫生—中药学]