姜黄属中药活血化瘀功效关联物质研究进展  

Efficacy-related substances of blood-activating and stasis-resolving medicinals derived from Curcuma plants:a review

作　　者：秦宇雯 费程浩 张伟[1,2] 李昱 徐祯 苏联麟 季德 毛春芹[1] 陆兔林[1] QIN Yu-wen;FEI Cheng-hao;ZHANG Wei;LI Yu;XU Zhen;SU Lian-lin;JI De;MAO Chun-qin;LU Tu-lin(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]安徽中医药大学药学院,安徽合肥230012

出　　处：《中国中药杂志》2022年第1期24-35,共12页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81973483);国家重点研发计划项目(2018YFC1707000)。

摘　　要：姜黄、莪术、片姜黄和郁金均属于姜黄属中药,是临床常用活血化瘀代表药,多用于治疗瘀血阻滞引起的闭经痛经,胸痹心痛,风湿痹痛等。现代研究表明,姜黄属中药中的标识性成分姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素、莪术二酮、吉马酮、莪术醇及β-榄香烯等均具有改善血液流变性、抗血小板聚集、抗血栓、抗炎、抗肿瘤、抗纤维化等活血化瘀作用。但因其基原、入药部位、炮制加工等方面存在异同,导致其功效和临床应用等方面也有所差异,而引起这种临床功效差异的关联物质尚未见系统研究。基于此,该文以功效关联物质为切入点,对姜黄属中药背景信息、功效及临床应用、功效关联物质及其"预测-识别-验证"研究方法等相关文献进行综述,为后期通过"整合证据链"的研究思路,阐明姜黄属中药活血化瘀功效"同中有异"的科学内涵及其临床合理用药提供理论依据。Derived from Curcuma plants,Curcumae Longae Rhizoma,Curcumae Rhizoma,Wenyujin Rhizoma Concisum,and Curcumae Radix are common blood-activating and stasis-resolving medicinals in clinical practice,which are mainly used to treat amenorrhea,dysmenorrhea,chest impediment and heart pain,and rheumatic arthralgia caused by blood stasis block.According to modern research,the typical components in medicinals derived from Curcuma plants,like curcumin,demethoxycurcumin,bisdemethoxycurcumin,curdione,germacrone,curcumol,andβ-elemene,have the activities of hemorheology improvement,anti-platelet aggregation,anti-thrombosis,anti-inflammation,anti-tumor,and anti-fibrosis,thereby activating blood and resolving stasis.However,due to the difference in origin,medicinal part,processing,and other aspects,the efficacy and clinical application are different.The efficacy-related substances behind the difference have not yet been systematically studied.Thus,focusing on the efficacy-related substances,this study reviewed the background,efficacy and clinical application,efficacy-related substances,and"prediction-identification-verification"research method of blood-activating and stasis-resolving medicinals derived from Curcuma plants,which is expected to lay a theoretical basis for the future research on the"similarities and differences"of such medicinals based on integrated evidence chain and to guide the scientific and rational application of them in clinical practice.

关 键 词：姜黄 莪术 片姜黄 郁金 活血化瘀 功效关联物质 

分 类 号：R285[医药卫生—中药学]