从国家自然科学基金资助项目浅谈中医药在恶性肿瘤治疗中的增效减毒作用研究现状  

Research status on efficacy enhancement and toxicity reduction of Chinese medicine in treatment of malignant tumors:a review of projects supported by National Natural Science Foundation of China

作　　者：刘学伟 娄彦妮[3] 冯哲 韩立炜[1] LIU Xue-wei;LOU Yan-ni;FENG Zhe;HAN Li-wei(Department of Health Sciences,National Natural Science Foundation of China,Beijing 100085,China;Mental Health College,Qiqihar Medical University,Qiqihar 161006,China;Department of Oncology of Integrated Chinese and Western Medicine,China-Japan Friendship Hospital,Beijing 100029,China;The First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]国家自然科学基金委员会医学科学部,北京100085 [2]齐齐哈尔医学院精神卫生学院,黑龙江齐齐哈尔161006 [3]中日友好医院中西医结合肿瘤科,北京100029 [4]南京中医药大学第一临床医学院,江苏南京210023

出　　处：《中国中药杂志》2022年第1期253-258,共6页China Journal of Chinese Materia Medica

摘　　要：该文通过对近十年国家自然科学基金中医药领域恶性肿瘤治疗中医药增效、减毒资助项目的回顾性分析,系统梳理和总结中医药在协同增效、减少毒副作用方面的主要研究内容与热点。分析发现,中医药增效作用主要包括改善分子靶向药物耐药、改善多药耐药、逆转化疗耐药、协同增效及放疗增敏等方面,而在减毒方面的作用主要体现在减轻放、化疗副作用。此外,中医药在减轻恶性肿瘤严重不良反应方面也体现了一定优势,为辅助肿瘤治疗提供更多的选择与策略。Through a retrospective analysis of the projects supported by the National Natural Science Foundation of China in the past ten years in the field of Chinese medicine for the treatment of malignant tumors,this article systematically summarized the main research contents and hotspots of Chinese medicine in efficacy enhancement and toxicity reduction.The efficacy enhancement of Chinese medicine mainly included the mitigation of molecule-targeted drug resistance,multidrug resistance,and chemotherapy resistance,synergistic efficacy enhancement,and radiotherapy sensitization.The toxicity reduction is mainly reflected in the alleviation of the side effects of radiotherapy and chemotherapy.In addition,Chinese medicine has advantages in reducing serious adverse reactions of malignant tumors,providing more options for the adjuvant treatment of tumors.

关 键 词：国家自然科学基金 中医药 肿瘤 增效 减毒 

分 类 号：R273[医药卫生—中西医结合]