Two approaches for newborns with critical congenital heart disease: a comparative study  

作　　者：Guan-Xi Wang Kai Ma Kun-Jing Pang Xu Wang Lei Qi Yang Yang Feng-Qun Mao Shou-Jun Li 

机构地区：[1]Pediatric Cardiac Surgery Center,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,No.167 Beilishi Street,Xicheng District,Beijing,100037,China [2]Department of Echocardiography,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,No.167 Beilishi Street,Xicheng District,Beijing,100037,China

出　　处：《World Journal of Pediatrics》2022年第1期59-66,共8页世界儿科杂志（英文版）

基　　金：This work was supported by National Key R&D Program of China(2017YFC1308100);Beijing Municipal Science&Technology Commission(Z201100005520001).

摘　　要：Background Prenatal diagnosis and planned peripartum care is an unexplored concept in China.This study aimed to evaluate the effects of the“prenatal diagnosis and postnatal treatment integrated model”for newborns with critical congenital heart disease.Methods The medical records of neonates(≤28 days)admitted to Fuwai Hospital were reviewed retrospectively from January 2019 to December 2020.The patients were divided into“prenatal diagnosis and postnatal treatment integrated group”(n=47)and“non-integrated group”(n=69).Results The age of admission to the hospital and the age at surgery were earlier in the integrated group than in the non-integrated group(5.2±7.2 days vs.11.8±8.0 days,P<0.001;11.9±7.0 days vs.16.5±7.7 days,P=0.001,respectively).The weight at surgery also was lower in the integrated group than in the non-integrated group(3.3±0.4 kg vs.3.6±0.6 kg,P=0.010).Longer postoperative recovery time was needed in the integrated group,with a median mechanical ventilation time of 97 h(interquartile range 51–259 h)vs.69 h(29–168 h)(P=0.030)and with intensive care unit time of 13.0 days(8.0–21.0 days)vs.9.0 days(4.5–16.0 days)(P=0.048).No significant difference was observed in the all-cause mortality(2.1 vs.8.7%,P=0.238),but it was significantly lower in the integrated group for transposition of the great arteries(0 vs.18.8%,log rank P=0.032).Conclusions The prenatal diagnosis and postnatal treatment integrated model could significantly shorten the diagnosis and hospitalization interval of newborns,and surgical intervention could be performed with a lower risk of death,especially for transposition of the great arteries.

关 键 词：Critical congenital heart diseases NEWBORN Prenatal diagnosis transposition of the great arteries 

分 类 号：R725.4[医药卫生—儿科]