育肾活血方治疗子宫腺肌病继发性痛经血瘀证的临床研究  

Clinical effect of Yushen Huoxue formula on adenomyosis secondary pain and blood stasis syndrome

作　　者：黄家宓 胡国华[1] 万怡婷 王佳云 谷灿灿 孔珏莹 宋艳华[1] 左玲[1] 陈静[1] HUANG Jiami;HU Guohua;WAN Yiting;WANG Jiayun;GU Cancan;KONG Jueying;SONG Yanhua;ZUO Ling;CHEN Jing(Hospital of Traditional Chinese Medicine affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《北京中医药大学学报》2022年第1期73-80,共8页Journal of Beijing University of Traditional Chinese Medicine

基　　金：上海市2020年度“科技创新行动计划”医学创新研究专项项目(No.20Y21900400);上海申康医院发展中心临床三年行动计划(No.SHDC2020CR4056);上海市中医诊疗模式创新试点建设项目(No.ZY(2018-2020)-FWTX-6006)。

摘　　要：目的观察育肾活血方对子宫腺肌病继发性痛经血瘀证的临床疗效。方法选取2020年1—10月就诊于上海市中医医院的子宫腺肌病继发性痛经血瘀证患者,共64例,按照随机数字表法分为试验组32例和对照组32例。试验组给予育肾活血方颗粒剂,对照组给予屈螺酮炔雌醇片,共治疗3个月。比较2组患者临床疗效、疼痛视觉模拟量表(VAS)评分、COX痛经症状量表(CMSS)评分、子宫腺肌病血瘀证中医证候积分、子宫体积,以及血清CA125、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)的含量。结果 2组患者治疗后VAS评分均较治疗前降低(P<0.01)。与治疗前比较,试验组患者治疗后痛经严重程度、痛经持续时间均降低(P<0.01),对照组患者治疗后痛经严重程度减轻(P<0.01)。与对照组治疗后比较,治疗后试验组患者痛经严重程度、痛经持续时间均降低(P<0.01)。与治疗前比较,2组患者治疗后中医证候积分均降低(P<0.01)。与对照组治疗后比较,治疗后试验组患者中医证候积分降低(P<0.01)。与治疗前比较,2组患者治疗后经期下腹固定性疼痛或刺痛症状均减轻(P<0.01)。试验组患者治疗后经血紫黯或有块体征及经期紊乱或量多症状减轻(P<0.01)。与对照组治疗后比较,治疗后试验组患者经期下腹固定性疼痛或刺痛、经血紫黯或有块、经期紊乱或量多积分均降低(P<0.05)。与治疗前比较,2组患者治疗后子宫体积缩小,血清CA125含量降低,血清SOD、CAT、GSH-PX含量升高(P<0.01)。与对照组治疗后比较,试验组患者治疗后子宫体积缩小,CA125含量降低,血清SOD、CAT、GSH-PX含量均升高(P<0.05,P<0.01)。结论育肾活血方能有效缓解子宫腺肌病继发性血瘀证痛经程度,缩短痛经时间,改善经血紫黯或有块、经期紊乱或量多的情况,缩小子宫体积,降低血清CA125含量,其作用机制可能与抗氧化作用有关。Objective To observe the clinical effect of Yushen Huoxue formula on patients with adenomyosis secondary pain and blood stasis syndrome. Methods A total of 64 patients with adenomyosis secondary to dysmenorrhea and blood stasis in the Shanghai Hospital of Traditional Chinese Medicine from January to October 2020. According to the random number table method, they were randomly divided into an experimental group(n=32) and a control group(n=32). The experimental group was given Yushen Huoxue formula and the control group was given drospiroone and ethenestradiol tablets for 3 months. Clinical efficacy, the pain VAS score, The Cox Menstrual Symptom Scale(CMSS) score, the adenomyosis blood stasis syndrome scale of traditional Chinese medicine, uterine volume, serum CA125 levels, and superoxide dismutase(SOD), catalase(CAT), and glutathione peroxidase(GSH-Px) contents were compared between both groups. Results The VAS scores of the two groups after treatment were lower than those before treatment(P< 0.01). The severity and duration of dysmenorrhea in the experimental group were reduced after treatment(P< 0.01), and the severity of dysmenorrhea in the control group was reduced after treatment(P< 0.01). Compared with the control group, the severity and duration of dysmenorrhea in the experimental group decreased after treatment(P< 0.01). The TCM symptom scores of the two groups decreased after treatment(P< 0.01). Compared with the control group, the score of TCM symptoms in the experimental group decreased after treatment(P<0.01). The symptoms of lower abdominal fixed pain or tingling in both groups were reduced after treatment(P< 0.01). After treatment, the patients in the experimental group had dark menstrual blood or blood clots, menstrual disorder, or menorrhagia, and the symptoms were relieved(P< 0.01). Compared with the control group, the scores of fixed pain or tingling of the lower abdomen during menstruation, dark menstrual blood or blood clots, menstrual disorder, or menorrhagia in the experimental group decreas

关 键 词：育肾活血方 子宫腺肌病继发性痛经 血瘀证 氧化应激 临床研究 

分 类 号：R271.11[医药卫生—中医妇科学]