急诊内镜金属钛夹与聚桂醇联合组织胶治疗肝硬化食管静脉曲张出血的临床效果比较  

Clinical Comparison of Emergency Endoscopic Titanium Clip and Lauromacrogol Combined with Tissue Glue in the Treatment of Esophageal Variceal Bleeding in Liver Cirrhosis

作　　者：张庆 常东歌 王丽红 ZHANG Qing;CHANG Dongge;WANG lihong(Department of Emergency,Zhengzhou Central Haspital Afiliated to Zhengzhou University,Zhengzhou 450000,China;Department of Gastroenterology,Zhengzhou Central Haspital Afiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院急诊科,河南郑州450000 [2]郑州大学附属郑州中心医院消化内科,河南郑州450000

出　　处：《河南医学研究》2022年第3期455-457,共3页Henan Medical Research

摘　　要：目的探讨急诊内镜金属钛夹与聚桂醇联合组织胶治疗肝硬化食管静脉曲张出血的临床效果。方法将郑州大学附属郑州中心医院2018年3月至2021年3月收治的60例肝硬化食管静脉曲张出血患者,按随机数表法分为对照组和观察组,各30例。对照组接受急诊内镜金属钛夹治疗,观察组在对照组基础上接受聚桂醇联合组织胶治疗。比较两组患者治疗后的临床指标(止血成功率、静脉曲张治疗有效率、近期再出血率、远期再出血率、住院时间和住院费用),比较治疗前后的血清丙二醛、过氧化脂、一氧化氮、一氧化氮合成酶水平以及并发症发生情况。结果观察组止血成功率和静脉曲张治疗有效率均高于对照组,近期再出血率和远期再出血率低于对照组(P<0.05);观察组住院时间短于对照组,住院费用低于对照组(P<0.05);与治疗前相比,治疗后两组患者血清丙二醛、过氧化脂、一氧化氮、一氧化氮合成酶水平均升高,但观察组低于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05)。结论急诊内镜金属钛夹与聚桂醇联合组织胶治疗肝硬化食管静脉曲张出血,可有效提高止血效果,减轻患者氧化应激反应,降低并发症发生率,疗效显著。Objective To investigate the clinical effect of emergency endoscopic titanium clip and lauromacrogol combined with tissue glue in the treatment of esophageal variceal bleeding in liver cirrhosis.Methods A total of 60 patients with esophageal variceal bleeding due to liver cirrhosis treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from March 2018 to March 2021 were randomly divided into control group and observation group,with 30 cases in each group.The control group received emergency endoscopic titanium clip,and the observat ion group received lauromacrogol combined with textile glue on the basis of the control group.The clinical indicators(success rate of hemostasis,the effective rate of variceal treatment and the short-term rebleeding rate,long-term rebleeding rate,hospitalization time and hospitalization expenses)were compared after treatment,and the levels of serum malondialdehyde,lipid peroxide,nitric oxide,nitric oxide synthase and complications were compared before and after treatment.Results The success rate of hemostasis and the effective rate of varicose vein treatment in the observation group were higher than those in the control group,and the short-termn rebleeding rate and long-termn rebleeding rate were lower than those in the control group(P<0.05).The hospitalization time of the observation group was shorter than that of the control group,and the hospitalization cost was lower than that of the control group(P<0.05).Compared with before treatment,the levels of serum malondialdehyde,lipid peroxide,nitric oxide and nitric oxide synthase in the two groups increased after treatment,but the levels in the observation group were lower than those in the control group(P<0.05).The incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion Emergency endoscopic tianium clip and lauromacrogol combined with tissue glue in the treatment of esophageal variceal bleeding in liver cirrhosis can effectively improve the hemostatic effect,reduc

关 键 词：肝硬化 食管静脉曲张出血 金属钛夹 聚桂醇 组织胶 

分 类 号：R512.6[医药卫生—内科学]