老年高血压患者颈动脉粥样硬化与动态脉压及脉压指数的关系分析  

Study on the relationship between carotid atherosclerosis and dynamic pulse pressure and pulse pressure index in elderly hypertensive patients

作　　者：刘靖 徐萍[1] 陶虹霏[1] 张书迪 吕美萱 高轶男 LIU Jing;XU Ping;TAO Hongfei;ZHANG Shudi;LYU Meixuan;GAO Yinan(Four Department of Cardiology,the Second Affiliated Hospital of Shenyang Medical College,Shenyang,Liaoning,110002,China)

机构地区：[1]沈阳医学院附属第二医院心四科,辽宁沈阳110002

出　　处：《当代医学》2022年第7期50-52,共3页Contemporary Medicine

摘　　要：目的探讨老年高血压患者动脉脉压、脉压指数与颈动脉粥样硬化之间的关系。方法选取2018年7月至2019年7月本院门诊收治的120例年龄>60岁的老年高血压患者作为研究对象,其中60例患者根据24 h血压动态脉压检测结果分为24 h动态脉压≥60 mmHg组(n=35)和24 h动态脉压<60 mmHg组(n=25),另外60例患者根据动态脉压指数分为脉压指数<0.40组(n=45)和脉压指数≥0.40组(n=15)。所有患者均为进行颈动脉超声检查和动态血压监测,观察动态脉压及脉压指数差异及患者动脉粥样硬化与动态脉压和脉压指数的相关性。结果经24 h血压动态监测,脉压≥60 mmHg组脉压指数、24 h收缩压、颈动脉内膜中层厚度、总胆固醇显著高于24 h动态脉压<60 mmHg组(P<0.05);脉压指数≥0.40组患者24 h血压动态脉压、24 h收缩压、颈动脉内膜中层厚度、总胆固醇高于脉压指数<0.40组,差异有统计学意义(P<0.05)。患者颈动脉内膜中层厚度与动态脉压指数及24 h内血压动脉脉压呈正相关(P<0.01)。结论老年高血压患者的颈动脉内膜中层厚度随着动态脉压指数和24 h血压动态脉压的升高而逐渐增大。Objective To explore the relationship between arterial pulse pressure,pulse pressure index and carotid atherosclerosis in elderly hy-pertensive patients.Methods A total of 120 elderly hypertensive patients aged>60 who were admitted to the outpatient clinic of our hospital from July 2018 to July 2019 were selected as the study subjects.According to the 24 h blood pressure ambulatory pulse pressure test,60 cases of patients were divided into pulse pressure≥60 mmHg group(n=35)and pulse pressure<60 mmHg group(n=25),and according to the dynamic pulse pres-sure index,another 60 cases of patients were divided into the pulse pressure index<0.40 group(n=45)and the pulse pressure index≥0.40 group(n=15).All patients participating in this study underwent carotid artery ultrasound examination and ambulatory blood pressure monitoring to observe the difference in ambulatory pulse pressure and pulse pressure index between the two groups and the correlation between atherosclerosis and ambulatory pulse pressure and pulse pressure index.Results The pulse pressure index,24 h systolic blood pressure,carotid intima-media thickness,and total cho-lesterol in the 24 h ambulatory pulse pressure≥60 mmHg group were significantly higher than those in the 24 h ambulatory pulse pressure<60 mmHg group(P<0.05).The 24 h blood pressure ambulatory pulse pressure,24 h systolic blood pressure,carotid intima-media thickness,and total cholesterol of patients in the pulse pressure index≥0.40 group were higher than those in the pulse pressure index<0.40 group,and the difference was statistically significant(P<0.05).The carotid intima-media thickness is positively correlated with the ambulatory pulse pressure index and blood pressure and arterial pulse pressure within 24 h(P<0.01).Conclusion The carotid intima-media thickness of elderly hypertensive patients gradually increases with the increase of ambulatory pulse pressure index and 24 h ambulatory pulse pressure.

关 键 词：高血压 颈动脉粥样硬化 动态脉压 脉压指数 

分 类 号：R544.1[医药卫生—心血管疾病]