基于涎腺超声评价中医药治疗原发性干燥综合征的临床疗效  

Evaluation of Clinical Efficacy of Traditional Chinese Medicine in the Treatment of Primary Sj?gren’s Syndrome Based on Salivary Gland Ultrasound

作　　者：刘丽 邵勤[1] 李延萍[1] 吴斌[1] LIU Li;SHAO Qin;LI Yan-ping;WU Bin

机构地区：[1]重庆市中医院,重庆400021 [2]重庆市大足区中医院,重庆402360

出　　处：《风湿病与关节炎》2022年第2期11-15,共5页Rheumatism and Arthritis

基　　金：重庆市科技局项目(cstc2018jxjl130084,cstc2019jscx-dxwtBX0023)。

摘　　要：目的:评价涎腺超声作为中医药治疗原发性干燥综合征临床疗效指标的可行性。方法:选取30例原发性干燥综合征患者为治疗组,15例健康体检者为正常对照组,筛选2组间涎腺超声的差异性指标。治疗组给予4个月的撤热存津颗粒治疗,从中医证候积分、欧洲抗风湿病联盟干燥综合征患者报告指数评分(ESSPRI评分)、欧洲抗风湿病联盟干燥综合征疾病活动度评分(ESSDAI评分)、红细胞沉降率(ESR)、唾液流率和超声等评价撤热存津颗粒的临床疗效。将涎腺超声与中医证候进行相关性分析。结果:治疗组与正常对照组的腮腺、颌下腺体积比较,差异无统计学意义(P > 0.05);涎腺体回声总分、腮腺评分、颌下腺评分比较,差异有统计学意义(P < 0.05)。治疗组中医证候总有效率为88.00%,ESSPRI评分总有效率为80.00%。治疗后中医证候积分、ESSPRI评分、ESSDAI评分、唾液流率、ESR较治疗前均明显改善(P < 0.05)。涎腺超声评价总有效率为84.00%,治疗前后涎腺超声评分比较,差异有统计学意义(P < 0.05)。经Spearman秩相关分析涎腺超声(回声)疗效与中医证候疗效呈正相关(P < 0.05)。结论:将涎腺超声(回声)用作原发性干燥综合征中医药疗效评估手段是可行的。Objective:To evaluate the feasibility of salivary gland ultrasound as a clinical efficacy index of traditional Chinese medicine in the treatment of primary Sj?gren’s syndrome.Methods:Thirty patients with primary Sj?gren’s syndrome were selected as a treatment group and fifteen healthy people as a normal control group.The different indexes of salivary gland ultrasound between the two groups were screened.The treatment group was treated with Cherecunjin Keli(撤热存津颗粒)for four months.The clinical efficacy of Cherecunjin Keli was evaluated from TCM syndrome score,ESSPRI score,ESSDAI score,ESR,salivary flow rate and ultrasound.The correlation between salivary gland ultrasound and TCM syndrome was analyzed.Results:There was no significant difference in the volume of parotid gland and submandibular gland between the treatment group and the normal control group(P > 0.05).There was significant difference in the total score of salivary gland echo,parotid gland score and submandibular gland score(P < 0.05).In the treatment group,the total effective rate of TCM syndrome was 88.00%,and the total effective rate of ESSPRI score was 80.00%.After treatment,TCM syndrome score,ESSPRI score,ESSDAI score,salivary flow rate and ESR were significantly improved compared with those before treatment(P < 0.05).The total effective rate of salivary gland ultrasound evaluation was 84.00%.There was a significant difference in salivary gland ultrasound score before and after treatment(P < 0.05).Spearman rank correlation analysis showed that the efficacy of salivary gland ultrasound(echo)was positively correlated with the efficacy of TCM syndrome(P < 0.05).Conclusion:It is feasible to use salivary gland ultrasound(echo)as a means to evaluate the efficacy of traditional Chinese medicine in primary Sj?gren’s syndrome.

关 键 词：原发性干燥综合征 涎腺超声 撤热存津颗粒 中医药 疗效评价 

分 类 号：R259[医药卫生—中西医结合]