PDGF-BB诱导主动脉平滑肌细胞表型转换的研究进展  

Advances in PDGF-BB induced aortic smooth muscle cell phenotype transition

作　　者：黄敏[1,2] 邱佳伟[1,2] 田海 吴杰[1,2,3] Huang Min;Qiu Jiawei;Tian Hai;Wu Jie(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China;Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China(Harbin Medical University),Ministry of Education,Harbin 150081,China;Future Medical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China;Department of Cardiovascular Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]中国遗传资源保护与疾病防控教育部重点实验室(哈尔滨医科大学),150081 [3]哈尔滨医科大学附属第二医院未来医学实验室,150081 [4]哈尔滨医科大学附属第二医院心血管外科,150081

出　　处：《国际遗传学杂志》2021年第5期332-338,共7页International Journal of Genetics

基　　金：国家自然科学基金(81770480);黑龙江省博士后科研启动资助(LBH-Q16163);哈尔滨医科大学伍连德科学青年基金(WLD-QN1701)。

摘　　要：血管平滑肌细胞(vascular smooth muscle cell,VSMC)的增殖、迁移和表型转换是多种心血管疾病,尤其是主动脉疾病发生发展的核心环节。血小板衍生生长因子(platelet derived growth factor,PDGF)是一类从损伤血管释放的强效有丝分裂原,其中PDGF-BB是诱导血管平滑肌细胞表型转换的开关之一,但其中具体的分子机制尚不清晰,本文就PDGF-BB诱导主动脉平滑肌细胞表型转换的可能机制进行归纳总结。Proliferation,migration and phenotypic switching of vascular smooth muscle cells(VSMC)are the critical links in the development of a variety of cardiovascular diseases,especially aortic diseases.Platelet derived growth factor(PDGF)is a powerful mitogen released from damaged blood vessels.Among them,platelet derived growth factor BB is one of the switches that induce the phenotypic switch of vascular smooth muscle cell,but its specific molecular mechanism is not completely clear.In present paper,we review the possible mechanism of PDGF-BB induced aortic smooth muscle cell phenotype transition.

关 键 词：PDGF-BB 主动脉血管平滑肌细胞 表型转换 信号通路 

分 类 号：R543.1[医药卫生—心血管疾病]