特发性中枢性性早熟女童子宫卵巢形态学的超声监测价值  

The value of ultrasonic monitoring of ovarian morphology in idiopathic central precocious puberty girls

作　　者：冯澜 黄海[1] 姚晓君 FENG Lan;HUANG Hai;YAO Xiaojun(Functional Department of Wuxi Ninth Hospital Affiliated to Suzhou University,Wuxi,Jiangsu 214000,China)

机构地区：[1]苏州大学附属无锡九院功能科,江苏无锡214000

出　　处：《中国优生与遗传杂志》2021年第10期1496-1499,共4页Chinese Journal of Birth Health & Heredity

摘　　要：目的分析特发性中枢性性早熟(ICPP)女童子宫卵巢形态学变化的超声监测价值。方法选取本院45例行促性腺激素释放激素类似物(GnRHa)治疗的ICPP女童(病例组),同期选取35例常规体检正常的女童(对照组)。两组均行超声检查,病例组经GnRHa治疗3个月。比较两组入组时超声影像学参数,包括子宫长径、子宫体积、卵泡最大直径、卵巢面积、卵巢体积、子宫内膜厚度、卵泡数目等。观察病例组治疗前后超声影像学参数的改善程度,检测病例组治疗前后血清性激素水平的变化情况。结果相比对照组,病例组治疗前子宫长径、子宫体积、卵泡最大直径、卵巢面积、卵巢体积、子宫内膜厚度均明显增大,卵泡数目明显增多(P<0.05),病例组经治疗后上述参数的水平均低于治疗前(P<0.05)。与治疗前比较,病例组治疗后血清性激素水平明显改善(P<0.05)。结论经超声观察ICPP女童子宫卵巢形态学的变化情况可间接评价其性腺轴功能的状况,客观评估GnRHa的临床疗效。Objective To analyze the value of ultrasonic monitoring of the morphological changes of uterus and ovary in girls with idiopathic central precocious puberty(ICPP).Methods 45 cases of ICPP girls(case group)treated with gonadotropin releasing hormone analogue(GnRHa)were selected in our hospital,and 35 normal girls(control group)were selected at the same time.Both groups were examined by ultrasonography,and the case group was treated with GnRHa for 3 months.The ultrasound imaging parameters were compared between the two groups,including uterine length,uterine volume,maximum diameter of follicles,ovarian area,ovarian volume,endometrial thickness,number of follicles,etc.The improvement of ultrasound imaging parameters and the changes of serum sex hormone levels in the case group before and after treatment were observed.Results Compared with the control group,the length of uterus,the volume of uterus,the maximum diameter of follicle,the area of ovary,the volume of ovary and the thickness of endometrium were significantly increased in the case group(P<0.05),and the above parameters were lower in the case group after treatment(P<0.05).Compared with the pre-treatment,the serum sex hormone level of the patients group was significantly improved(P<0.05).Conclusion The changes of ovarian morphology in ICPP girls can be used to evaluate the function of gonadal axis indirectly and objectively evaluate the clinical effect of GnRHa.

关 键 词：特发性中枢性性早熟 超声 子宫 卵巢形态学 

分 类 号：R725.8[医药卫生—儿科]