生物被膜胞外多聚物与铜绿假单胞菌耐药相关性的研究进展  

Research progress on the relationship between the extracellular polymeric substance of biofilms and the drug resistance of Pseudomonas aeruginosa

作　　者：石磊[1] 商庆龙[1] Shi Lei;Shang Qinglong(Department of Microbiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学微生物学教研室,150081

出　　处：《国际遗传学杂志》2021年第6期452-456,共5页International Journal of Genetics

基　　金：黑龙江省自然科学基金(H2016009)。

摘　　要：铜绿假单胞菌耐药涉及基因突变为基础的多种通路和成份。近年来, 除耐药基因通路调控外, 铜绿假单胞菌胞外多聚物的组分研究取得进展, eDNA、sRNA和噬菌体等多种核酸物质, 以及胞外囊泡为代表的新组分和新机制被发现。胞外多聚物的研究进展为铜绿假单胞菌耐药的研究提供了新思路。本文将对铜绿假单胞菌生物被膜中的胞外多聚物相关组分与耐药性的研究进展状况作一综述。Drug resistance of Pseudomonas aeruginosa involves a variety of pathways and components based on gene mutation.In addition to the regulation of drug-resistant gene pathways,the study on the components of the extracellular polymers of Pseudomonas aeruginosa has made progress,and a variety of nucleic acid substances such as eDNA,sRNA and phage,as well as the extracellular vesicles represented by new components and new mechanisms have been found.The research progress of extracellular polymers provides a new idea for the study of drug resistance of Pseudomonas aeruginosa.This paper will review the research progress of the components extracellular polymer-related and its relationship with drug resistance in Pseudomonas aeruginosa.

关 键 词：铜绿假单胞菌 胞外多聚物 耐药 

分 类 号：R378[医药卫生—病原生物学]