甘露醇对创伤性脑水肿及AQP4表达影响的研究进展  

Mannitol in the treatment of traumatic brain edema and its effect on AQP4 expression

作　　者：艾莉 鲁宏[1,2] 林治华 AI Li;LU Hong;LIN Zhihua(Department of Medical Imaging, The Seventh People’s Hospital of Chongqing, Chongqing 400054, China;College of pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China)

机构地区：[1]重庆市第七人民医院,重庆400054 [2]重庆理工大学药学与生物工程学院,重庆400054

出　　处：《重庆理工大学学报（自然科学）》2022年第2期232-237,共6页Journal of Chongqing University of Technology：Natural Science

基　　金：重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0353)。

摘　　要：创伤性脑水肿是脑外伤最为好发的并发症之一,其致死率及致残率均高,对人类健康造成了极大威胁。甘露醇是临床高频使用的高渗脱水剂,具有快速降颅压的特点,但其不良反应也逐渐被重视。AQP4在创伤性脑水肿的产生与进展中扮演着相当重要的角色。深入研究甘露醇、创伤性脑水肿、AQP4三者间的联系,以及甘露醇对创伤性脑水肿、AQP4表达影响的作用机制,有利于解决甘露醇治疗创伤性脑水肿所面临的问题,也有助于临床寻求更优化的治疗方案。Traumatic brain edema(TBE)is the most common complication of traumatic brain injury,with high mortality and disability rate,which pose a great threat to human health.Mannitol is a kind of hypertonic dehydrating agent,which is used to treat cerebral edema in clinic.It has the characteristics of reducing intracranial pressure rapidly.However,its adverse reactions can not be ignored,and in recent years,more and more attention has been paid.AQP4 plays an important role in the development of traumatic brain edema.Further study of the relationship among mannitol,traumatic brain edema and AQP4,as well as the mechanism of mannitol’s effect on traumatic brain edema and AQP4 expression,will help to solve the problems faced by mannitol in the treatment of traumatic brain edema,and also help to seek a more optimized treatment plan.

关 键 词：甘露醇 脑水肿 QP4 

分 类 号：R453.9[医药卫生—治疗学]