直肠充盈对直肠壁CT影像组学特征的影响  

Effects of rectal filling on CT radiomics features of rectal wall

作　　者：张白霖 黄泽裕 戴振晖 朱琳 杨耕 靳怀志 高蕾 王学涛 ZHANG Bailin;Huang Zeyu;DAI Zhenhui;ZHU Lin;YANG Geng;JIN Huaizhi;GAO Lei;WANG Xuetao(Department of Radiotherapy in Guangzhou Higher Education Mega Center,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,China;School of Medical Information Engineering,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学第二附属医院大学城放射治疗区,广东广州510006 [2]广州中医药大学医学信息工程学院,广东广州510006

出　　处：《中国医学物理学杂志》2022年第2期194-197,共4页Chinese Journal of Medical Physics

基　　金：教育部产学合作协同育人项目(201902119002);广东省医学科研基金(A2019196)。

摘　　要：目的:探讨直肠充盈对直肠壁CT影像组学特征的影响。方法:收集95例宫颈癌后装治疗定位CT扫描图像,患者在直肠填充苦参凝胶前后分别进行CT扫描,手动勾画直肠壁,计算提取7类共计851个特征,包括形态、统计、灰度相关矩阵、灰度游程矩阵、灰度共生矩阵、灰度区域矩阵及邻域灰度差分矩阵特征,采用一致性相关系数评估特征稳定性,威尔科克森符号秩检验分析直肠充盈对直肠壁CT影像组学特征的影响。结果:直肠充盈前后较稳定(一致性相关系数值小于0.8)的特征占总数的13%(113/851),有显著性差异(P<0.05)的特征占总数的92%(782/851)。结论:直肠充盈对直肠壁CT影像组学特征影响较大,应予以关注。Objective To investigate the effects of rectal filling on the CT radiomics features of rectal wall.Methods The positioning CT images of 95 patients treated by brachytherapy for cervical cancer were collected.CT scans were performed before and after rectal filling with KUSHEN Ningjiaos,and the rectal wall was manually delineated.A total of 851 features in 7 categories were calculated and extracted,including morphology,first order statistical feature,grey level dependence matrix,grey level run length matrix,gray level co-occurrence matrix,grey level size zone matrix and neighborhood grey-tone difference matrix.The stability of features was evaluated using concordance correlation coefficient(CCC),and the effects of rectal filling on the CT radiomics features of rectal wall was analyzed by Wilcoxon signed rank test.Results The comparison before and after rectal filling revealed that 13%(113/851)of the features remained stable(CCC<0.8),and that features with significant difference(P<0.05)accounted for 92%(782/851).Conclusion The rectal filling which has a great effect on the CT radiomics features of rectal wall should be of concern.

关 键 词：影像组学 直肠 直肠充盈 直肠壁 计算机断层扫描 

分 类 号：R815[医药卫生—放射医学]