一种2-氯-5-氯甲基噻唑的合成提纯方法及应用  

The Apply and the Method of the Synthesis and Purification for 2-Chloro-5-Chloromethylthiazole

作　　者：高艳[1] 马克娥 段元红 张佩佩 Gao Yan;Ma Kee;Duan Yuanhong;Zhang Peipei(Shandong Institute of the Control of Agrochemicals,Jinan 250100,China)

机构地区：[1]山东省农药检定所,山东济南250100

出　　处：《山东化工》2022年第2期4-6,共3页Shandong Chemical Industry

摘　　要：2-氯-5-氯甲基噻唑作为一种农药中间体,在新烟碱类杀虫剂的合成中,扮演着重要的角色。本文简述了一种2-氯-5-氯甲基噻唑的合成及提纯的方法,并对影响收率及含量的因子进行了实验研究,结果表明,当反应温度为10℃,二氯乙烷的加入量为260 g,盐酸的用量为267 g时,反应效果最佳,收率可以达到90%以上,含量99%。2-chloro-5-chloromethylthiazole as an pesticide intermediate,it plays an important role in the synthesis of neonicotinoid insecticides.It is described a method for the synthesis and purification of 2-chloro-5-chloromethylthiazole.The factors affecting the yield and content were studied experimentally,and it turns out that,the reaction temperature is 10℃,the mass of dichloroethane is 260 g,the mass of hydrochloric acid is 267 g,the reaction result is the best,the yield is over 90%and the content is 99%。

关 键 词：2-氯-5-氯甲基噻唑 农药 合成 提纯 

分 类 号：TQ252.5[化学工程—有机化工]