冠心病患者冠状动脉支架植入术前血清LOX-1表达与术后冠脉再狭窄发生的关系研究  

Study on the Relationship Between Serum LOX-1 Expression Before Percutaneous Coronary Intervention and Occurrence of Postoperative Coronary Restenosis in Patients with Coronary Heart Disease

作　　者：冯艳鹤 胡丽娜 FENG Yanhe;HU Li'na(Department of Internal Medicine,the People'sHospital of Xiangcheng County,Xuchang 461700,China)

机构地区：[1]河南省襄城县人民医院内科,河南许昌461700

出　　处：《临床医学工程》2022年第2期171-172,共2页Clinical Medicine & Engineering

基　　金：2019年河南省医学科技攻关计划联合共建项目(项目编号:LHGJ20190506AD)。

摘　　要：目的探讨冠心病(CHD)患者冠状动脉支架植入(PCI)术前血清LOX-1表达与术后冠脉再狭窄发生的关系。方法选取行PCI治疗的98例CHD患者,检测术前血清LOX-1水平,统计术后冠脉再狭窄发生情况,分析术前血清LOX-1表达与PCI术后冠脉再狭窄的相关性。结果98例CHD患者PCI术后冠脉再狭窄发生率为9.18%;冠脉再狭窄患者的术前血清LOX-1水平显著高于冠脉无再狭窄患者(P<0.05);ROC曲线显示术前血清LOX-1水平预测CHD患者PCI术后冠脉再狭窄发生的AUC值为0.738,具有一定预测性能。结论CHD患者PCI术后冠脉再狭窄的发生与其术前血清LOX-1表达密切相关。Objective To explore the relationship between serum LOX-1 expression before percutaneous coronary intervention(PCI)and occurrence of postoperative coronary restenosis in patients with coronary heart disease(CHD).Methods 98 patients with CHD who underwent PCI were selected.The preoperative serum LOX-1 level was detected and the occurrence of postoperative coronary restenosis after surgery was counted to analyze the relationship between preoperative serum LOX-1 expression and occurrence of postoperative coronary restenosis.Results The incidence of coronary restenosis after PCI in 98 CHD patients was 9.18%.The preoperative serum LOX-1 level in patients with coronary restenosis was significantly higher than that in patients without coronary restenosis(P<0.05).ROC curve showed that the A UC value of preoperative serum LOX-1 level in predicting the occurrence of coronary restenosis after PCI in CHD patients was 0.738,which had certain predictive performance.Conclusions The occurrence of coronary restenosis after PCI in CHD patients is closely related to the preoperative serum LOX-1 expression.

关 键 词：冠心病 冠状动脉支架植入 血清LOX-1 冠脉再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]