基于口感改善的中药临方制剂依从性提高策略探讨  

Exploration on compliance enhancement strategy of personalized traditional Chinese medicine preparations based on taste improvement

作　　者：吴飞[1] 夏新凤 葛改变 洪燕龙[3] 王优杰[1] 胡佳亮[1] 王荣荣 林晓[2] WU Fei;XIA Xinfeng;GE Gaibian;HONG Yanlong;WANG Youjie;HU Jialiang;WANG Rongrong;LIN Xiao(Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Traditional Chinese Medicine Health Service Collaborative Innovation Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Taizhou Medical New&Hi-tech Industrial Development Zone,Taizhou 225300,Jiangsu,China)

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203 [2]上海中医药大学中药学院,上海201203 [3]上海中医药大学中医健康服务协同创新中心,上海201203 [4]泰州医药高新技术产业园,江苏泰州225300

出　　处：《上海中医药大学学报》2022年第1期1-7,共7页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81973490);上海市“科技创新行动计划”技术标准项目(20DZ2200900);上海市自然科学基金资助项目(18ZR1436600);上海市科技计划项目(21DZ2271000);上海市卫健委科研基金资助项目(201940296,202140347);上海中医药慢性病防治与健康服务省部共建协同创新中心项目(2021科技02-37)。

摘　　要：随着相关技术的发展、法规的鼓励和临床需求的上升,中药临方制剂的发展逐步进入了快车道。与成方制剂相比,中药临方制剂更能体现个性化治疗理念;与传统汤剂相比,临方制剂在解决不良口感所致临床依从性差等问题方面具有明显优势。若综合应用矫味/掩味策略,临方制剂将更能从口感的角度满足患者的个性化需求。在建立中药特征气、味感官指纹图谱的基础上,通过相应的矫味/掩味策略,可以有效改善中药临方制剂不同类型的不良口感,并进一步提高其临床依从性。具体手段包括从剂型和处方设计角度进行口感提升,基于患者口感偏好、体质和情绪特点进行相应的矫味/掩味方案设计,通过个性化的包装手段提升产品的品质和患者服用的依从性。此外,与成方制剂不同的是,中药临方制剂产品使用周期短,其矫味/掩味策略和技术手段更为灵活,个性化矫味伴侣的应用具有可行性,剂型、辅料的选择更加丰富。同时,一些常用矫味/掩味辅料安全性的最新报道亦应受到关注。With the development of related technologies,encouragement by regulations and rising clinical demands,the development of personalized traditional Chinese medicine(TCM)preparations is gradually accelerated. Compared with the fixed prescription TCM preparations,personalized TCM preparations could better reflect the personalized treatment concept;compared with the traditional decoction,personalized TCM preparations have significant advantage in solving the clinical compliance problem caused by unpleasant taste.In view of the personalized TCM preparation,the application of taste masking technology could meet the individual needs of patients from the perspective of taste. Based on the establishment of TCM sensory characteristic fingerprints of ordor and taste,the different types of uncomfortable tastes of personalized TCM preparations could be effectively improved and its clinical compliance is further enhanced through the corresponding taste masking strategies. The main methods include improving the taste from the perspective of dosage form and prescription design,designing the taste masking scheme based on the taste preference,physical condition and emotional features of the patients,enhancing the product quality and the compliance of the patients through the personalized package design. In addition,compared with fixed prescription TCM preparations,because of the short life cycle of the product usage of personalized TCM preparations,the taste masking strategies and technical means have more flexibility,the application of personalized mate for taste masking has feasibility,and the choices of dosage forms and excipient types are more abundant. Meanwhile,the latest safety reports of some commonly used taste masking excipients should also be concerned.

关 键 词：中药临方制剂 矫味/掩味 临床依从性 个性化矫味伴侣 

分 类 号：R283.6[医药卫生—中药学]