基于质构特征物理性质的中药临方凝胶贴膏涂布性能研究  

Study on coatability of personalized gel plasters of traditional Chinese medicine based on characteristic physical properties of texture

作　　者：朱森发 杨光[1] 李文杰[1] 赵立杰[2] 杜若飞[2] 张磊[1] 鲜洁晨[2] 洪燕龙[1] ZHU Senfa;YANG Guang;LI Wenjie;ZHAO Lijie;DU Ruofei;ZHANG Lei;XIAN Jiechen;HONG Yanlong(Shanghai Traditional Chinese Medicine Health Service Collaborative Innovation Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Innovative Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中医健康服务协同创新中心,上海201203 [2]上海中医药大学创新中药研究院,上海201203

出　　处：《上海中医药大学学报》2022年第1期63-74,共12页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81973490);上海市自然科学基金资助项目(18ZR1436600);上海市“科技创新行动计划”技术标准项目(20DZ2200900);上海市中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-2001-03];上海中医药慢性病防治与健康服务省部共建协同创新中心项目(2021科技02-37);上海市科技计划项目(21DZ2271000);中药制药过程新技术国家重点实验室开放基金计划项目(SKL2020Z0205)。

摘　　要：目的:探究基质用量与涂布前膏体质构特征物理性质(特征物理性质)、贴膏涂布性能之间的相关性。方法:以贴膏成型质量和涂布性能为指标,选取部分中和的聚丙烯酸钠(NP700)、甘羟铝等6个重要辅料基质进行处方设计,每种基质用量设定为5个水平,共计30首处方。采用物性测定仪对30首不同处方、7个不同时间点的210个涂布前膏体样品的涂抹性、硬度、黏弹性等特征物理性质参数进行测定,运用相关性分析、主成分分析等方法对数据进行处理。结果:随基质NP700、聚维酮K30、酒石酸用量及油相比例的增大,涂布前膏体的涂抹性、硬度、稠度、提拉强度、内聚力、变化速率及黏弹性特征物理性质参数均相应增大,适宜的涂布时间缩短,容易出现皱布现象。在对样品特征物理性质参数进行主成分分析后,210个样品可明显分为可涂布和不可涂布样品两大类。结论:通过减少基质NP700、聚维酮K30、酒石酸用量及油相比例,可降低涂布前膏体涂抹性、硬度、稠度、内聚力等特征物理性质参数,从而对贴膏的涂布性能进行优化。Objective:To explore the correlation among the amount of matrix,the characteristic physical properties of texture(characteristic physical properties)of the paste before coating and the coatability of the strapping.Methods:Taking the modeling quality and coatability of the strapping as the indicators,six important excipient matrices including partially neutralized sodium polyacrylate(NP700),aluminum glycolate and so on were selected for formulation design. The amount of each matrix was set to 5 levels,and a total of 30 prescriptions were obtained. The characteristic physical properties including spreadability,hardness,viscoelasticity and so on of 210 samples of the paste before coating which were from 30 different prescriptions and 7 different time points were measured by a texture analyzer. The correlation analysis,principal component analysis and other methods were used to process the data.Results:With the increasing of the dosage of NP700,povidone K30 and tartaric acid and the ratio of oil phase,the indicators of characteristic physical properties of the paste before coating including spreadability,hardness,consistency,tensile strength,cohesion,rate of change and viscoelasticity were correspondingly increased. The suitable coating time was shortened,and the phenomenon of wrinkling was more likely appeared. After the principal component analysis on the characteristic physical property indicators of the samples,210 samples can be clearly divided into two categories:coating and non-coating samples.Conclusion:By reducing the amount of NP700,povidone K30 and tartaric acid and the ratio of oil phase,the characteristic physical property indicators of the paste before coating such as spreadability,hardness,consistency and cohesion can be decreased,so as to optimize the coatability of the strapping.

关 键 词：中药临方制剂 凝胶贴膏 基质处方 特征物理性质 涂布性能 

分 类 号：R283.6[医药卫生—中药学]