中国9个长寿地区65岁及以上人群血硒水平与虚弱的关联研究  

Association of blood selenium levels with frailty in the older adults aged 65 years and above in nine longevity areas of China

作　　者：刘俊鑫 魏源 陈晨[2] 周锦辉 熊家惠 王君[2] 罗宇菲 李晨峰 赵峰[2] 吕跃斌 皮静波[1] 施小明[2] LIU Jun-xin;WEI Yuan;CHEN Chen;ZHOU Jin-hui;XIONG Jia-hui;WANG Jun;LUO Yu-fei;LI Chen-feng;ZHAO Feng;LYU Yue-bin;PI Jing-bo;SHI Xiao-ming(School of Public Health,China Medical University,Shenyang 110001,China;China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention;School of Public Health,Jilin University;School of Public Health,Anhui Medical University)

机构地区：[1]中国医科大学公共卫生学院,沈阳110001 [2]中国疾病预防控制中心环境与人群健康重点实验室中国疾病预防控制中心环境与健康相关产品安全所 [3]吉林大学公共卫生学院 [4]安徽医科大学公共卫生学院

出　　处：《环境卫生学杂志》2022年第1期5-11,共7页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金项目(82025030,82003550,81872707,81941023)。

摘　　要：目的探讨中国长寿地区65岁及以上老年人血硒水平与虚弱患病风险的关系。方法数据来源于"老年健康生物标志物队列研究"项目,以2017—2018年调查的中国9个长寿地区2464名65岁及以上老年人为研究对象,通过问卷调查获得调查对象的人口学特征、生活方式、饮食习惯及健康状况等信息,同时使用虚弱指数量表评定调查对象的虚弱程度,收集空腹静脉血,以电感耦合等离子体质谱法检测硒的内暴露水平。根据血硒水平的四分位数将研究对象分为4组(Q_(1)~Q_(4)组),采用多因素Logistic回归模型分析血硒水平与虚弱的关系,采用限制性立方样条模型研究血硒水平与虚弱之间的暴露反应关系。结果2464名研究对象年龄为(84.55±11.38)岁,其中男性1180名(47.89%),女性1284名(52.11%);非虚弱者1866名(75.73%),虚弱者为598名(24.27%)。男性和女性血硒水平的几何均数分别为109.73和108.33μg/L;(65~79)、(80~89)、(90~99)和≥100岁老年人血硒水平的几何均数分别为119.15、106.54、102.12、98.04μg/L。采用多因素Logistic回归模型调整相关混杂因素后,与血硒水平Q_(1)组老年人相比,血硒水平较高者虚弱的患病风险较低,Q_(2),Q_(3),Q_(4)组的OR(95%CI)值分别为0.68(0.49~0.96)、0.65(0.46~0.92)和0.59(0.40~0.87)。限制性立方样条模型分析显示,血硒水平与老年人虚弱的患病风险呈非线性暴露反应关系(P_(非线性)<0.01)。结论我国9个长寿地区65岁及以上老年人血硒水平与虚弱患病风险存在负向关联。Objective To explore the relationship between blood selenium levels and the risk of prevalent frailty in old adults aged 65 years and above in longevity areas of China.Methods The data were obtained from the 2017—2018 cross-sectional study of the Healthy Aging and Biomarkers Cohort Study.A total of 2464 older adults aged 65 years and above were included from 9 longevity areas of China.A questionnaire survey was conducted to investigate the demographic variables,life style,eating habits,health status and other information.The frailty index was used to assess the degree of frailty of the participants.The fasting venous blood was collected and measured by ICP-MS to obtain the internal exposure level of selenium.According to the quartiles of blood selenium levels,the participants were divided into 4 groups(Q_(1)-Q_(4)).A multivariate logistic regression model was used to analyze the relationship between blood selenium and frailty,and the restricted cubic spline was used to investigate the exposure-response relationship between blood selenium and frailty.Results The 2464 participants were aged 84.55±11.38 years,with 1180(47.89%)males and 1284(52.11%)females,of whom 1866(75.73%)were non-frail and 598(24.27%)were frail.The geometric mean blood selenium levels of men and women were 109.73μg/L and 108.33μg/L,respectively;the geometric mean blood selenium levels of older adults aged 65-79,80-89,90-99,and≥100 were 119.15,106.54,102.12,and 98.04μg/L,respectively.After adjusting the confounding factors using a multivariate logistic regression model,the results showed that compared with the older adults in the Q_(1) group,those in the Q_(2),Q_(3),and Q_(4) groups with higher blood selenium concentrations had lower odds of prevalent frailty(odds ratios were 0.68,0.65,and 0.59,respectively,95%CI:0.49-0.96,0.46-0.92,and 0.40-0.87,respectively).The restricted cubic spline model showed that there was a nonlinear exposure-response relationship between blood selenium concentration and the risk of prevalent frailty in the olde

关 键 词：微量元素 硒 老年人 虚弱 

分 类 号：R12[医药卫生—环境卫生学]