固相萃取GC-MS测定饮用水中8种亚硝胺化合物  

Determination of 8 nitrosamine compounds in drinking water by SPE-GC-MS

作　　者：苏广宁[1] 钟秀华[1] 邓靖 邵义娟 方磊 钟志雄[1] 余胜兵[1] 鲁琳[1] 连晓文[1] SU Guang-ning;ZHONG Xiu-hua;DENG Jing;SHAO Yi-juan;FANG Lei;ZHONG Zhi-xiong;YU Sheng-bing;LU Lin;LIAN Xiao-wen(Guangdong Provincial Center for Disease Control and Prevention Institute of public health service testing,Guangzhou 511430,China)

机构地区：[1]广东省疾病预防控制中心卫生化验所,广州511430

出　　处：《环境卫生学杂志》2022年第1期64-69,共6页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：广东省医学科学技术研究基金项目(A2020054)。

摘　　要：目的建立同时测定饮用水中8种亚硝胺化合物的方法。方法水样中加入内标物,用椰壳炭固相萃取柱进行富集、净化和浓缩,气相色谱—质谱(GC-MS)法分析,内标法定量。结果8种亚硝胺化合物在(10~250)ng/L的线性范围内线性关系良好(相关系数r>0.998),方法检出限在(1.26~3.00)ng/L,定量限在(4.20~10.0)ng/L。水样低、中、高浓度亚硝胺化合物加标的回收率为78.6%~116%,相对标准偏差(RSD)在1.50%~11.1%。本方法对水源水、末梢水进行测定,结果满意。结论本方法操作简便、灵敏度高、稳定可靠,能够满足生活饮用水及其水源水中8种亚硝胺化合物的检测要求。Objective To establish a method for simultaneous determination of 8 nitrosamine compounds in drinking water by solid phase extraction-gas chromatography-mass spectrometry(SPE-GC-MS).Methods After adding internal standards,water samples were enriched,purified,and concentrated through a SPE column packed by coconut shell-derived activated carbon and determined by GC-MS,with the internal standard samples for quantification.Results The linear range of 8 nitrosamine compounds was between 10 and 250 ng/L,with a good linear relationship(correlation coefficient r>0.998).The limit of detection was(1.26-3.00)ng/L,and the limit of determination was(4.20-10.0)ng/L.For water samples with low,medium,and high concentrations of nitrosamine compounds,the recovery rate ranged from 78.6%to 116%,and the relative standard deviation ranged from 1.50%to 11.1%.This method provided satisfactory results for the determination of source water and terminal water.Conclusion This method is simple,sensitive and stable,which can meet the requirements for the determination of the 8 nitrosamine compounds in drinking water and source water.

关 键 词：亚硝胺 气相色谱—质谱(GC-MS) 固相萃取 饮用水 

分 类 号：R123[医药卫生—环境卫生学] O657[医药卫生—公共卫生与预防医学]