双歧杆菌三联活菌散治疗小儿急性感染性腹泻的临床效果  

Clinical efficacy of Bifidobacterium triptans in the treatment of pediatric acute infectious diarrhea

作　　者：赵扬扬 杨晓林 陈欢欢 李娟 Zhao Yangyang;Yang Xiaolin;Chen Huanhuan;Li Juan(Department of Pediatrics,Yellow River Sanmenxia Hospital,Sanmenxia Henan 472000,China)

机构地区：[1]黄河三门峡医院儿科,河南三门峡472000

出　　处：《保健医学研究与实践》2021年第6期78-81,共4页Health Medicine Research and Practice

基　　金：河南省医学科技攻关计划项目(20180209856)。

摘　　要：目的探讨双歧杆菌三联活菌散治疗对急性感染性腹泻患儿炎症因子、肠道菌群及免疫功能的影响。方法选取2017年9月—2019年9月河南省某医院收治的132例急性感染性腹泻患儿为研究对象,采用随机数字表法分为对照组与观察组,每组66例。对照组患儿采用蒙脱石散治疗,观察组患儿采用双歧杆菌三联活菌散治疗,比较2组患儿的临床疗效,治疗前后血清内毒素、白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平,肠道菌群水平,以及外周血T淋巴细胞亚群CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比值水平。结果观察组患儿治疗总有效率为98.48%,高于对照组的87.88%,差异有统计学意义(χ^(2)=4.293,P=0.038)。2组患儿治疗后血清内毒素、IL-6、TNF-α、CRP水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后血清CD4^(+)、CD4^(+)/CD8^(+)比值水平高于治疗前,且高于对照组,差异均有统计学意义(P<0.05)。观察组患儿治疗后肠道双歧杆菌水平及B/E高于对照组,肠杆菌水平低于对照组,差异均有统计学意义(P<0.05)。结论双歧杆菌三联活菌散治疗小儿急性感染性腹泻,可抑制患儿体内炎症反应、调节患儿肠道菌群水平,提高患儿免疫功能。Objective To investigate the effects of bifidobacterium triptans treatment on inflammatory factors,intestinal flora and immune function in children with acute infectious diarrhea.Methods One hundred and thirtytwo cases of children with acute infectious diarrhea admitted to a hospital in Henan Province from September 2017 to September 2019 were selected for the study and were divided into a control group and an observation group using the random number table method,with 66 cases in each group.The children in the control group were treated with montelukast,and the children in the observation group were treated with Bifidobacterium triptans,and the clinical efficacy,serum endotoxin,interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)levels,intestinal flora levels,and peripheral blood T-lymphocyte subpopulation CD4^(+),CD8^(+),CD4^(+)/CD8^(+)ratio levels before and after the treatment were compared between the two groups.Results The total effective rate of treatment for the children in the observation group was 98.48%,which was lower than that of the control group(87.88%),and the difference was statistically significant(χ^(2)=4.293,P=0.038).Serum endotoxin,IL-6,TNF-αand CRP levels in the two groups were lower than those before treatment and higher in the observation group,and the difference was statistically significant(P<0.05).The serum CD4^(+)and CD4^(+)/CD8^(+)ration levels in the observation group after treatment were higher than those before treatment and higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of intestinal bifidobacteria and B/E of children in the observation group were higher than those in the control group after treatment,and the level of enterobacteriaceae was lower than that in the control group,and the differences were all statistically significant(P<0.05).Conclusion The treatment of acute infectious diarrhea in children with bifidobacterium triptans can suppress the inflammatory reaction,regulate the level of i

关 键 词：双歧杆菌三联活菌散 小儿急性感染性腹泻 炎症因子 肠道菌群 

分 类 号：R725.7[医药卫生—儿科]