四逆加人参汤治疗癌因性疲乏临床观察  

Clinical Observation of Sini plus Renshen Decoction(四逆加人参汤) in Treatment of Fatigue Caused by Cancer

作　　者：曹旭 甘蕾[1] 王勇飞[1] 顾伯林[1] 吴悦 陆玉峰[1] CAO Xu;GAN Lei;WANG Yongfei;GU Bolin;WU Yue;LU Yufeng(The Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu,China)

机构地区：[1]苏州大学附属第二医院,江苏苏州215004

出　　处：《中华中医药学刊》2022年第1期58-60,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81803553)。

摘　　要：目的评价四逆加人参汤用于治疗肿瘤患者放疗后、化疗后或术后相关性癌因性疲乏的有效性和安全性。方法选择2017年3月—2019年12月中医科门诊及病房收治的68例肿瘤患者,随机分为治疗组、对照组。对照组接受常规治疗。治疗组加用四逆加人参汤治疗。结果观察组治疗后总有效率为97.06%(33/34),高于对照组的总有效率76.47%(26/34)(P<0.05)。观察组治疗后躯体疲乏、情感疲乏、认知疲乏评分均低于对照组(P<0.05)。治疗后,两组CD;T细胞比例、CD^(+)_(4)/CD^(+)_(8)比值比较,观察组高于对照组。治疗后,两组CD^(+)_(8)T细胞比例比较,观察组低于对照组(P<0.05)。治疗后两组KPS评分均高于本组治疗前,观察组KPS评分高于对照组(P<0.05)。结论四逆加人参汤可减轻肿瘤患者癌因性疲劳临床症状,改善生活质量,提高临床治疗效果及免疫功能,具有临床推广意义。Objective To evaluate the effect and safety of Sini plus Renshen Decoction(四逆加人参汤)in the treatment of cancer patients with cancer-related fatigue after radiotherapy,chemotherapy or surgery.Method A total of 68 cancer patients treated in outpatient and ward of traditional Chinese medicine department from March 2017 to December 2019 were randomly divided into treatment group and control group.The control group received routine treatment.The treatment group was treated with Sini plus Renshen Decoction.Results The total effective rate after treatment in the observation group(97.06%,33/34)was higher than that in the control group(76.47%,26/34)(P<0.05).The scores of physical fatigue,emotional fatigue and cognitive fatigue in the observation group were lower than those of the control group after treatment(P<0.05).After treatment,the ratio of CD+4 T cells and the ratio of CD^(+)_(4)/CD^(+)_(8) in the observation group were higher than those in the control group,and the ratio of CD^(+)_(8) T cells was lower than that in the control group(P<0.05).The KPS scores of the two groups after treatment were higher than those before treatment,and the KPS scores of the observation group were higher than those of the control group(P<0.05).Conclusion Sini plus Renshen Decoction can improve cancer-induced fatigue symptoms and quality of life in cancer patients,improve clinical treatment effects and immune function,and has clinical promotion significance.

关 键 词：四逆加人参汤 癌因性疲乏 生活质量 免疫功能 

分 类 号：R273[医药卫生—中西医结合]