少腹逐瘀汤治疗慢性盆腔炎临床疗效及对血清免疫球蛋白的影响  

Clinical Effect of Shaofu Zhuyu Decoction(少腹逐瘀汤)on Chronic Pelvic Inflammation and Its Effect on Serum Immunoglobulin

作　　者：褚冬梅[1] 刘荣霞[1] 张莹[1] 赵振钏[1] CHU Dongmei;LIU Rongxia;ZHANG Ying;ZHAO Zhenchuan(Shijiazhuang Fourth Hospital,Shijiazhuang 050000,Hebei,China)

机构地区：[1]石家庄市第四医院,河北石家庄050000

出　　处：《中华中医药学刊》2022年第1期157-160,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省自然科学基金(H2014105093)。

摘　　要：目的观察少腹逐瘀汤治疗慢性盆腔炎的临床疗效及对血清免疫球蛋白的影响。方法依据随机数字表法将2017年3月—2020年4月医院收治的慢性盆腔炎患者128例分为研究组和对照组,每组64例。对照组口服左氧氟沙星治疗,0.2 g/次,3次/d。研究组在对照组治疗的基础上,口服少腹逐瘀汤治疗。连续治疗2周。比较两组治疗疗效、中医证候积分、腰骶胀痛、下腹冷痛和带下量多消失时间,比较治疗前后患者的免疫球蛋白水平[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和免疫球蛋白G(IgG)],比较两组治疗前后血清炎症因子水平[肿瘤坏死因子(TNF-α)、白细胞介素-8(IL-8)和Ⅰ型血红素氧合酶(HO-1)]。结果研究组治疗总有效率为90.63%(58/64),对照组治疗总有效率为76.56%(49/64),研究组治疗总有效率高于对照组(P<0.05);两组治疗后中医主症腰骶胀痛、白带异常、冷痛评分和次症月经失调、形寒肢冷评分均较治疗前降低,研究组改善幅度优于对照组(P<0.05);研究组患者治疗后腰骶胀痛、下腹冷痛和带下量多消失时间低于对照组(P<0.05);两组治疗后血清免疫球蛋白IgA、IgM和IgG水平低于治疗前,且研究组降低幅度优于对照组(P<0.05);两组治疗后血清炎症因子TNF-α、IL-8和HO-1水平较治疗前降低,研究组降低幅度优于对照组(P<0.05)。结论少腹逐瘀汤结合左氧氟沙星可有效的改善慢性盆腔炎患者的临床症状,改善免疫功能,降低炎症因子水平,缩短治疗时间,提高治疗疗效,有较好的临床应用前景。Objective To observe the clinical effect of Shaofu Zhuyu Decoction(少腹逐瘀汤)on chronic pelvic inflammation and its effect on serum immunoglobulin.Methods According to the random number table method,128 patients with chronic pelvic inflammation admitted to our hospital from March 2017 to April 2020 were divided into study group and control group,64 patients in each group.The control group received oral levofloxacin 0.2 g once,three times a day.The study group was treated with Shaofu Zhuyu Decoction orally on the basis of the control group.The treatment continued for 2 weeks.The therapeutic effects of the two groups were compared,including TCM syndrome scores,the disappearing time of lumbosacral swelling pain,lower abdominal cold pain and morbid leucorrhea.The levels of immunoglobulin(IgA,IgM and IgG)and serum inflammatory factors(TNF-α,IL-8 and HO-1)of the two groups were compared before and after treatment.Results The total effective rate was 90.63%(58/64)in the study group and 76.56%(49/64)in the control group.The total effective rate in the study group was higher than that in the control group(P<0.05).After treatment,the scores of lumbosacral swelling pain,abnormal leucorrhea,cold pain score,secondary menstrual disorder and cold limb score were all lower in the two groups than those before treatment.The improvement range of the study group was better than that of the control group(P<0.05).The treatment time of the patients in the study group was lower than that in the control group(P<0.05).After treatment,serum levels of IgA,IgM and IgG in the two groups were lower than those before treatment,and the reduction rate of the study group was better than that of the control group(P<0.05).The serum levels of inflammatory cytokines TNF-α,IL-8 and HO-1 in the two groups were lower after treatment than those before treatment,and the reduction in the study group was better than that in the control group(P<0.05).Conclusion Shaofu Zhuyu Decoction combined with levofloxacin can effectively improve the clinical symp

关 键 词：少腹逐瘀汤 左氧氟沙星 慢性盆腔炎 寒湿凝滞型 免疫球蛋白 影响 

分 类 号：R271.911.33[医药卫生—中西医结合]