小柴胡汤联合厄贝沙坦对高血压患者肠道菌群及脂代谢影响  

Effects of Xiaochaihu Decoction(小柴胡汤) Combined with Irbesartan on Intestinal Flora and Lipid Metabolism in Patients with Hypertension

作　　者：吴山永 姜宁华[1] 石彦波 赵西斌[2] 郭志丽 刘金涛[2] 胡艳艳 WU Shanyong;JIANG Ninghua;SHI Yanbo;ZHAO Xibin;GUO Zhili;LIU Jintao;HU Yanyan(The Second Affiliated Hospital of Jiaxing University,Jiaxing 314000,Zhejiang,China;Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314000,Zhejiang,China)

机构地区：[1]嘉兴学院附属第二医院,浙江嘉兴314000 [2]嘉兴市中医院,浙江嘉兴314000

出　　处：《中华中医药学刊》2022年第1期169-172,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划(2020ZB252)。

摘　　要：目的探讨小柴胡汤联合厄贝沙坦对高血压患者肠道菌群及脂代谢影响。方法选取医院收治的高血压病患者98例,随机分为两组各49例。对照组给予厄贝沙坦,实验组在对照组基础上联用小柴胡汤,对比两组临床疗效、舒张压(DBP)和收缩压(SBP)值、脂代谢情况、血清炎性因子水平、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰转肽酶(γ-GT)水平及肠道菌群变化。结果治疗后,实验组总有效率明显较高(P<0.05);两组治疗前DBP和SBP差异无统计学意义(P>0.05);两组治疗后DBP和SBP值显著降低(P<0.05);并且实验组降低较明显(P<0.05);两组治疗前肠道菌群差异无统计学意义(P>0.05);对照组治疗前后肠球菌、酵母菌、肠杆菌、拟杆菌、乳杆菌、双岐杆菌差异无统计学意义(P>0.05);实验组治疗后肠球菌、酵母菌、肠杆菌显著低于对照组,拟杆菌、乳杆菌、双岐杆菌显著较高(P<0.05);治疗前后对照组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平差异无统计学意义(P>0.05);实验组治疗后血清IL-6、TNF-α和CRP水平显著低于对照组(P<0.05);对照组治疗前后血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平差异无统计学意义(P>0.05);实验组治疗后血清TG、TC和LDL-C水平显著低于对照组,HDL-C水平显著高于对照组(P<0.05);两组治疗前AST、ALT和γ-GT水平差异无统计学意义(P>0.05);对照组治疗前后AST、ALT和γ-GT水平差异无统计学意义(P>0.05);实验组治疗后AST、ALT和γ-GT水平显著低于对照组(P<0.05)。结论小柴胡汤联合厄贝沙坦可改善高血压患者脂代谢,降低血压,可调节肠道菌群紊乱,具有较好的治疗效果,值得在临床上推广应用。Objective To investigate the effects of Xiaochaihu Decoction(小柴胡汤)combined with irbesartan on intestinal flora and lipid metabolism in patients with hypertension.Methods A total of 98 patients with hypertension admitted to our hospital were randomly divided into two groups,49 cases in each group.Thrombolytic therapy was given to patients in both groups,irbesartan was given to patients in the control group,and Xiaochaihu Decoction was given to patients in the experimental group on the basis of the control group.The clinical efficacy,DBP and SBP values,lipid metabolism,serum inflammatory factor levels,levels of AST,ALT andγ-GT and intestinal microflora of two groups were compared.Results After treatment,the total effective rate of the experimental group was higher(P<0.05).DBP and SBP were not significantly different between the two groups before treatment(P>0.05).DBP and SBP values were significantly decreased in both groups after treatment(P<0.05).Those of the experimental group decreased significantly(P<0.05).There was no difference in intestinal flora between the two groups before treatment(P<0.05).Enterococcus,yeast,Enterobacter,Bacteroidetes,Lactobacillus and Bifidobacterium had no significant difference before and after treatment in the control group(P>0.05).After treatment,Enterococcus,yeast and Enterobacter in the experimental group were significantly lower than those in the control group,while Bacteroides,Lactobacillus and Bifidobacter were significantly higher than those in the control group(P<0.05).Serum levels of IL-6,TNF-αand CRP in control group were not significantly different before and after treatment(P>0.05).The levels of serum IL-6,TNF-αand CRP in experimental group were significantly lower after treatment(P<0.05).The serum levels of TG,TC,HDL-C and LDL-C in the control group were not significantly different before and after treatment(P>0.05).After treatment,the serum levels of TG,TC and LDL-C in the experimental group were significantly lower,and the level of HDL-C was significantly h

关 键 词：小柴胡汤 厄贝沙坦 高血压 肠道菌群 脂代谢 

分 类 号：R259.441[医药卫生—中西医结合]