腹主动脉瘤患者D-二聚体水平及其与腹主动脉瘤最大直径、腔内血栓厚度相关性分析  

D-dimer level in patients with abdominal aortic aneurysm and its correlation with maximum diameter of abdominal aortic aneurysm and intraluminal thrombus thickness

作　　者：田原 陈伟志 牛玉军 TIAN Yuan;CHEN Weizhi;NIU Yujun(Department of Radiology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)

机构地区：[1]锦州医科大学附属第一医院放射科,辽宁锦州121001

出　　处：《陕西医学杂志》2022年第3期325-329,共5页Shaanxi Medical Journal

基　　金：辽宁省科技厅计划项目(2019JH8/10300035)。

摘　　要：目的:检测腹主动脉瘤(AAA)患者D-二聚体水平,并分析其与腹主动脉瘤最大直径、腔内血栓厚度的相关性。方法:收集确诊为AAA并接受住院治疗的患者50例为AAA组。选取同期入院、年龄和性别与AAA组基本匹配且经影像学检查排除AAA的患者50例为对照组。比较两组D-二聚体、C-反应蛋白(CRP)、白蛋白(ALB)及C反应蛋白与白蛋白比值(CAR),分析D-二聚体水平与AAA存在的关系。依据AAA最大直径将50例AAA患者分为大瘤体组(直径≥5.0 cm,26例)和小瘤体组(直径<5.0 cm,24例),比较两组患者上述指标以及AAA最大直径、腔内血栓厚度,分析D-二聚体水平与AAA最大直径和腔内血栓厚度间的相关性。结果:与对照组相比,AAA组D-二聚体、CRP、CAR显著增高,ALB显著降低(均P<0.01)。D-二聚体是AAA存在的独立预测因子(P<0.01)。大瘤体组AAA最大直径、D-二聚体水平和腔内血栓厚度明显高于小瘤体组(均P<0.01)。AAA患者D-二聚体水平与AAA最大直径、腔内血栓厚度之间存在正相关关系(r=0.506、0.418,均P<0.01)。AAA患者AAA最大直径与腔内血栓厚度之间存在正相关关系(r=0.701,P<0.01)。结论:AAA患者D-二聚体水平明显升高,且与AAA最大直径和腔内血栓厚度呈正相关,有望成为预测AAA发生与发展的生物学指标。Objective:To detect the level of D-dimer in patients with abdominal aortic aneurysm(AAA)and analyze its correlation with the maximum diameter of AAA and intraluminal thrombus thickness.Methods:Fifty patients diagnosed as AAA were collected as AAA group.Fifty patients whose age and gender basically matched the AAA group and excluded AAA by imaging examination in the same period were selected as the control group.D-dimer,C-reactive protein(CRP),albumin(ALB)and C-reactive protein to albumin ratio(CAR)were compared between the two groups,and the relationship between D-dimer level and AAA was analyzed.According to the maximum diameter of AAA,50 patients with AAA were divided into large tumor group(diameter≥5.0 cm,26 cases)and small tumor group(diameter<5.0 cm,24 cases).The above indexes,AAA maximum diameter and intraluminal thrombus thickness of the two groups were compared,and the correlation between D-dimer level and AAA maximum diameter and intraluminal thrombus thickness was analyzed.Results:Compared with the control group,D-dimer,CRP and CAR were significantly increased and ALB was significantly decreased in AAA group(all P<0.01).D-dimer was an independent predictor of AAA(P<0.01).The AAA maximum diameter,D-dimer level and intraluminal thrombus thickness in the large tumor group were significantly higher than those in the small tumor group(all P<0.01).There was a positive correlation between the D-dimer level and AAA maximum diameter and intraluminal thrombus thickness in patients with AAA(r=0.506,0.418,all P<0.01).There was a positive correlation between the AAA maximum diameter and intraluminal thrombus thickness in patients with AAA(r=0.701,P<0.01).Conclusion:The level of D-dimer in patients with AAA is significantly increased,and is positively correlated with the AAA maximum diameter and intraluminal thrombus thickness.It is expected to be a biological index to predict the occurrence and development of AAA.

关 键 词：腹主动脉瘤 D-二聚体 腔内血栓 CT血管造影 多平面重建 C反应蛋白与白蛋白比值 

分 类 号：R543.16[医药卫生—心血管疾病]