精子核蛋白组型转换对首次宫腔内人工授精临床结局的影响  

The effect of sperm nucleoprotein transition on the clinical outcome of the first intrauterine insemination cycle

作　　者：周欢群[1] 陆杉[1] 谢妍[1] 李思楠 陈旭龙[1] 周文[1] Zhou Huanqun;Lu Shan;Xie Yan;Li Sinan;Chen Xulong;Zhou Wen(Department of Reproductive Medicine,Traditional Chinese Medical Hospital of Guangdong Province,Guangzhou Guangdong 510006,P.R.China)

机构地区：[1]广东省中医院生殖医学科,广东广州510006

出　　处：《中国计划生育和妇产科》2022年第2期56-59,共4页Chinese Journal of Family Planning & Gynecotokology

基　　金：广东省中医药局科研项目(项目编号:20212078)。

摘　　要：目的研究精子核蛋白组型转换对首次宫腔内人工授精(intrauterine insemination, IUI)临床结局的影响。方法对2017年3月至2021年2月于广东省中医院生殖医学科完成的168个首次IUI周期临床资料及术前3个月内的精子核蛋白组型转换数据进行回顾性分析,根据精子核蛋白组型转换异常率(AB阳性率)分为:AB阳性率<30%组(132例)和AB阳性率≥30%组(36例),比较两组IUI临床妊娠率、自然流产率,分析精子核蛋白组型转换预测IUI临床妊娠的价值。根据妊娠结局,将所有患者分为妊娠组(34例)与未妊娠组(134例),将临床妊娠患者分为自然流产组(8例)与未流产组(26例),比较其精子核蛋白组型转换异常率。结果 AB阳性率<30%组与AB阳性率≥30%组的首次IUI临床妊娠率、自然流产率比较,差异均无统计学意义(P>0.05)。妊娠组与未妊娠组、自然流产组与未流产组精子核蛋白组型转换异常率比较,差异均无统计学意义(P>0.05)。ROC曲线显示,精子核蛋白组型转换异常率不能预测IUI临床妊娠(AUC=0.554,95%CI:0.449-0.660,P=0.328)。结论精子核蛋白组型转换对IUI临床结局无明显影响。Objective To research effects of sperm nucleoprotein transition on clinical outcomes of the first intrauterine insemination(IUI) cycle.Methods Clinical data of the first IUI cycle and the sperm nucleoprotein transition data were retrospectively analyzed in the Department of Reproductive Medicine of Traditional Chinese Medicine Hospital of Guangdong Province from March 2017 to February 2021.168 IUI cycles were divided into: AB<30% group(132 cases) and AB≥30% group(36 cases) according to the sperm nucleoprotein abnormal rate(AB positive rate),IUI clinical pregnancy rate and spontaneous abortion rate were compared between two groups, and ROC curve was used to analyze the value of sperm nucleoprotein transition to predict IUI clinical pregnancy.Moreover, all patients were divided into pregnant group(34 cases) and non-pregnant group(134 cases) according to pregnancy outcomes, and clinical pregnant patients were divided into spontaneous abortion group(8 cases) and non-abortion group(26 cases),the abnormal rate of sperm nucleoprotein transition were compared between two groups.Results There was no significant difference in clinical pregnancy rate and spontaneous abortion rate between AB<30% group and AB≥30% group(P>0.05).There was no significant difference in sperm nucleoprotein abnormal rate between the pregnant group and the non-pregnant group, the spontaneous abortion group and the non-abortion group(P>0.05).ROC curve showed that the abnormal rate of sperm nucleoprotein could not predict IUI clinical pregnancy(AUC=0.554,95% CI:0.449-0.660,P=0.328).Conclusion The sperm nucleoprotein transition abnormal rate shows no significant effect on the clinical outcome of IUI.

关 键 词：精子核蛋白组型转换异常率 IUI 临床妊娠 自然流产 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学] R698.2[医药卫生—基础医学]