抗精神病药物引起骨质疏松症的机制及研究进展  

Mechanisms and research progress of bone metabolism diseases caused by antipsychotics

作　　者：刘语清 伊思敏 李杰 王婷云 翁飞鸿 李申[2] Liu Yuqing;Yi Simin;Li Jie;Wang Tingyun;Weng Feihong;Li Shen(School of Basic Medicine,Tianjin Medical University,Tianjin 300070,China;Department of Mental Health and Psychology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学基础医学院,300070 [2]天津医科大学精神卫生与心理学系,300070

出　　处：《神经疾病与精神卫生》2022年第2期134-138,共5页Journal of Neuroscience and Mental Health

摘　　要：骨质疏松症是抗精神病药物的常见不良反应,其症状是以低骨密度为特征,导致骨脆性增加、畸形和骨折的全身性进行性骨骼疾病。以利培酮为代表的抗精神病药物使用会导致高泌乳素血症,高水平催乳素能够通过刺激骨吸收、降低性激素水平影响骨代谢。然而高乳素血症学说存在一定的局限性。现通过探讨人骨代谢指标的变化、动物体内骨量变化和对成骨细胞的作用三个层面对精神病药物影响骨代谢的各种可能途径予以综述,以期提高抗精神病药物与骨代谢异常关系的认识,为临床中减轻抗精神病药物所致的骨质疏松提供依据。Osteoporosis is a common side effect of antipsychotic drugs.Osteoporosis is a systemic progressive bone disease characterized by low bone mineral density,resulting in increased bone fragility,deformity,and fracture.The use of certain antipsychotic drugs such as risperidone can lead to hyperprolactinemia,and high levels of prolactin can affect bone metabolism by stimulating bone resorption and reducing sex hormone levels.However hyperprolactinemia theory has certain limitation.This paper reviews the possible ways of the effects of psychotropic drugs on bone metabolism from three aspects:the changes of human bone metabolism indexes,the changes of bone mass in animals and the effects on osteoblasts,in order to improve the understanding of the relationship between antipsychotics and abnormal bone metabolism,and provide clues for reducing osteoporosis caused by antipsychotics in clinic.

关 键 词：抗精神病药物 骨质疏松 骨密度减低 精神分裂症 综述 

分 类 号：R969.3[医药卫生—药理学]