金橘化学成分的研究(Ⅰ)  

Chemical constituents from Fortunella margarita

作　　者：王倩[1] 刘宏栋[1] 刘勇[2] 刘红宁[3] 陈杰[3] 李斌[1] WANG Qian;LIU Hong-dong;LIU Yong;LIU Hong-ning;CHEN Jie;LI Bin(Academician Workstation,Jiangxi University of Chinese Medicine,Nanchang 330004,China;School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Research Center for Differentiation and Development of Basic Theories of Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学院士工作站,江西南昌330004 [2]江西中医药大学药学院,江西南昌330004 [3]江西中医药大学中医基础理论分化发展研究中心,江西南昌330004

出　　处：《中成药》2022年第2期450-456,共7页Chinese Traditional Patent Medicine

基　　金：江西省2011协同创新项目(JXXT2018002)。

摘　　要：目的研究金橘Fortunella margarita(Lour.)Swingle的化学成分。方法金橘成熟果实95%乙醇提取物采用硅胶、ODS、MCI、Sephadex LH-20以及半制备HPLC进行分离纯化,根据理化性质和波谱数据鉴定所得化合物结构。结果从中分离得到17个化合物,分别鉴定为无羁萜(1)、α-香树脂醇(2)、β-谷甾醇(3)、羽扇豆醇(4)、β-香树脂醇(5)、柠檬苦素(6)、表无羁萜醇(7)、滨蒿内酯(8)、东莨菪内酯(9)、citrusinine-Ι(10)、山柰酚(11)、芦丁(12)、(+)-nyasol(13)、金柑苷(14)、acacetin-8-C-neohesperidoside(15)、syringaresinol 4′-O-β-D-glucopyranoside(16)、vanilloloside(17)。结论化合物1~2、4~5、7~10、13、16~17为首次从该植物中分离得到,化合物16为金橘属植物中首次分离得到。AIM To study the chemical constituents from Fortunella margarita(Lour.)Swingle.METHODS The 95% ethanol extract of F.margarita was isolated and purified by silica,ODS,MCI,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seventeen compounds were isolated and identified as friedelin(1),α-amyrin(2),β-sitosterol(3),lupeol(4),β-amyrin(5),limonin(6),epifriedelinol(7),scoparone(8),scopoletin(9),citrusinine-Ι(10),kaempferol(11),rutin(12),(+)-nyasol(13),fortunellin(14),acacetin-8-C-neohesperidoside(15),syringaresinol 4′-O-β-D-glucopyranoside(16),vanilloloside(17).CONCLUSION Compounds 1-2,4-5,7-10,13,16-17 are isolated from this plant for the first time,and compound 16 is isolated from genus Rutaceae for the first time.

关 键 词：金橘 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]