乌药叶化学成分的研究  

Chemical constituents from the leaves of Lindera aggregata

作　　者：孙崇鲁[1] 俞松林[1] 李士敏[1] 袁莉霞 王芙蓉 彭昕 SUN Chong-lu;YU Song-lin;LI Shi-min;YUAN Li-xia;WANG Fu-rong;PENG Xin(Zhejiang Pharmaceutical College,Ningbo 315100,China;Ningbo Research Institute of Zhejiang University,Ningbo 315100,China)

机构地区：[1]浙江医药高等专科学校,浙江宁波315100 [2]浙江大学宁波研究院,浙江宁波315100

出　　处：《中成药》2022年第2期464-469,共6页Chinese Traditional Patent Medicine

基　　金：浙江省公益基础研究项目(LGN21H280003);宁波市自然基金项目(2019A610374,2019A610414)。

摘　　要：目的研究乌药Lindera aggregate(Sims) Kosterm叶的化学成分。方法乌药叶70%乙醇提取物采用硅胶、Sephadex LH-20、制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为hydroxylinderstrenolide(1)、lindenanolide H(2)、lindenanolide A(3)、atractylenolideⅢ(4)、chlojaponilactone A(5)、9,9′-dihydroxy-3,4-methylenedioxy-3′-methoxy[7-O-4′,8-5′] lignans(6)、槲皮素(7)、山柰酚(8)、槲皮素-3-O-β-D-木糖苷(9)、槲皮素-3-O-α-L-阿拉伯呋喃糖苷(10)、山柰酚-3-O-α-L-鼠李糖苷(11)、山柰酚-3-O-(4″-反式-对-香豆酰基)-α-L-鼠李糖苷(12)、山柰酚-3-O-(2″,4″-二-反式-对-香豆酰基)-α-L-鼠李糖苷(13)。结论其中化合物2~6、12~13为首次从该植物中分离得到。AIM To study the chemical constituents from the leaves of Lindera aggregate(Sims) Kosterm.METHODS The 70% ethanol extract from the leaves of L.aggregate was isolated and purified by silica,Sephadex LH-20,and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Thirteen compounds were isolated and identified as hydroxylinderstrenolide(1),lindenanolide H(2),lindenanolide A(3),atractylenolide Ⅲ(4),chlojaponilactone A(5),9,9′-dihydroxy-3,4-methylenedioxy-3′-methoxy[7-O-4′,8-5′] lignans(6),quercetin(7),kaempferol(8),quercetin-3-O-β-D-xylopyranoside(9),quercetin-3-O-α-L-arabinofuranoside(10),kaempferol-3-O-α-L-rhamnoside(11),kaempferol-3-O-(4″-E-p-coumaroyl)-α-L-rhamnoside(12),kaempferol-3-O-(2″,4″-di-E-p-coumaroyl)-α-L-rhamnoside(13).CONCLUSION Compounds 2-6,12-13 are isolated from this plant for the first time.

关 键 词：乌药叶 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]