术前单次静脉注射酮咯酸氨丁三醇对学龄前儿童七氟醚麻醉后苏醒期躁动的影响  

作　　者：胡洁[1] 王璐[1] 

机构地区：[1]上海交通大学医学院附属上海儿童医学中心麻醉科,上海200127

出　　处：《中国药业》2021年第S02期6-7,共2页China Pharmaceuticals

摘　　要：目的探讨术前单次静脉注射酮咯酸氨丁三醇对学龄前儿童七氟醚麻醉后苏醒期躁动(EA)的影响。方法择取全麻下行腹腔镜斜疝修补术的学龄前儿童80例,随机分为酮咯酸氨丁三醇组(K组)和对照组(C组),各40例。划皮前K组患儿静脉注射酮咯酸氨丁三醇0.5 mg/kg(最大剂量15 mg),C组静脉注射等量生理盐水。两组患儿均吸入七氟醚维持麻醉。记录患儿EA及不良反应发生情况。结果K组患儿EA发生率及严重程度低于C组患儿(P<0.05),两组患儿不良反应发生率无显著差异。结论术前单次注射酮咯酸氨丁三醇能降低七氟醚麻醉下腹腔镜斜疝修补术学龄前儿童EA的发生率及严重程度。Objective To investigate the effect of preoperative single intravenous injection of ketorolac tromethamine on agitation(EA)in preschool children after sevoflurane anesthesia.Methods A total of 80 preschool children undergoing laparoscopic indirect hernia repair under general anesthesia were randomly divided into the ketorolac tromethamine group(group K)and control group(group C),with 40 cases in each group.Before skin incision,ketorolac tromethamine 0.5 mg/kg(the maximum dose was 15 mg)was injected intravenously in group K,and the same amount of normal saline was injected intravenously in group C.Both groups inhaled sevoflurane to maintain anesthesia.EA and adverse reactions were recorded.Results The incidence and severity of EA in group K were lower than those in group C(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion A single preoperative injection of ketorolac tromethamine can reduce the incidence and severity of EA in preschool children undergoing laparoscopic indirect hernia repair under sevoflurane anesthesia.

关 键 词：酮咯酸氨丁三醇 苏醒期躁动 七氟醚 药品不良反应 

分 类 号：R971.2[医药卫生—药品]