瞬时受体电位香草酸亚型1受体介导疼痛的机制和治疗应用研究进展  

Research progress on the mechanism of transient receptor potential vanilloid 1 receptor mediating pain and the therapeutic application

作　　者：程旭韬(综述) 华震(审校) CHENG Xu-tao;HUA Zhen(Graduate School of Peking Union Medical College, Department of Anesthesiology, Beijing Hospital, Beijing 100005, China)

机构地区：[1]北京医院麻醉科,北京协和医学院研究生院,北京100005

出　　处：《中国临床新医学》2022年第2期171-175,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：北京医院临床研究“121工程”项目(编号:BJ-2020-168)。

摘　　要：瞬时受体电位香草酸亚型1(TRPV1)自首次成功克隆以来作为与疼痛密切相关的伤害性感受器而备受关注,其分子结构与生理功能、分布特征、激活与抑制等得到广泛研究。TRPV1受体参与炎症、脂质氧化等生物过程也与疼痛息息相关。多种内、外源性增敏剂或抑制剂可调节TRPV1通道敏感性,从而介导疼痛信号传导。TRPV1还可能通过细胞内钙超载等机制导致伤害性感受器的消融,这可能是镇痛治疗的一种潜在有效途径。该文旨在对TRPV1受体介导疼痛的相关机制及其应用研究进展作一综述。Transient receptor potential vanilloid 1(TRPV1)has attracted much attention as a nociceptor closely related to pain since its first successful cloning,and its molecular structure,physiological function,distribution characteristics,activation and inhibition have been widely studied.TRPV1 receptor is also closely related to pain in terms of its involvement in biological processes such as inflammation and lipid oxidation.A variety of endogenous and exogenous sensitizers or inhibitors can modulate the sensitivity of TRPV1 channel,thus mediating pain signal transmission.TRPV1 may also lead to the ablation of nociceptors through intracellular calcium overload and other mechanisms,which may be a potential effective approach in the treatment of pain.The aim of this paper is to review the research progress on the related mechanisms and the applications of TRPV1 receptor in mediating pain.

关 键 词：瞬时受体电位香草酸亚型1 辣椒素受体 慢性疼痛 伤害性感受器 

分 类 号：R614[医药卫生—麻醉学]