肥胖型多囊卵巢综合征患者血浆VLDL-C、RBP水平与心血管疾病风险的关系  

Relationship between plasma VLDL-C,RBP levels and risk of cardiovascular disease in patients with obesity polycystic ovary syndrome

作　　者：沈霞 龚敏 徐勇 居蓉 SHEN Xia;GONG Min;XU Yong;JU Rong(Department of Gynecology,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu 211100,China;Department of Clinical Laboratory,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu 211100,China)

机构地区：[1]南京医科大学附属江宁医院妇科,江苏南京211100 [2]南京医科大学附属江宁医院检验科,江苏南京211100

出　　处：《国际检验医学杂志》2022年第5期545-548,553,共5页International Journal of Laboratory Medicine

基　　金：江苏省卫生和计划生育委员会医学科研课题(H2017043)。

摘　　要：目的探讨肥胖型多囊卵巢综合征(PCOS)患者血浆中极低密度脂蛋白胆固醇(VLDL-C)、视黄醇结合蛋白(RBP)表达情况及二者与心血管疾病风险的相关性。方法选择2018年8月至2021年2月在该院妇科治疗的PCOS患者260例作为研究对象,根据体质量指数(BMI)将患者分为肥胖型组(BMI≥25 kg/m^(2))128例和非肥胖型组(BMI<25 kg/m^(2))132例;根据有无心血管疾病将肥胖型组患者分为无心血管疾病组73例和心血管疾病组55例;收集患者临床资料,采用酶联免疫吸附法检测血浆VLDL-C、RBP水平,Pearson法分析血浆VLDL-C、RBP与各临床资料指标的相关性,受试者工作特征(ROC)曲线分析血浆VLDL-C、RBP对肥胖型PCOS患者发生心血管疾病的预测价值。结果肥胖型组患者BMI、腰臀比(WHR)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)、血浆VLDL-C、RBP水平高于非肥胖型组,高密度脂蛋白胆固醇(HDL-C)水平低于非肥胖型组,差异有统计学意义(均P<0.05);心血管疾病组患者血浆VLDL-C、RBP水平高于无心血管疾病组,差异有统计学意义(P<0.05);血浆VLDL-C、RBP与BMI、WHR、HbA1c、HOMA-IR、TC、LDL-C、hs-CRP水平均呈正相关(均P<0.05),与HDL-C水平均呈负相关(均P<0.05);血浆VLDL-C与RBP水平呈正相关(P<0.05);血浆VLDL-C与RBP联合预测肥胖型PCOS患者发生心血管疾病灵敏度为81.82%,特异度为95.89%,曲线下面积(AUC)为0.943。结论血浆VLDL-C、RBP水平与肥胖型PCOS患者发生心血管疾病有关,可作为预测肥胖型PCOS患者心血管疾病风险的潜在标志物。Objective To explore the expression of very low density lipoprotein-cholesterol(VLDL-C)and retinol binding protein(RBP)in the plasma of obese patients with polycystic ovary syndrome(PCOS)and their correlation with the risk of cardiovascular disease.Methods Two hundred and sixty patients with PCOS treated in Jiangning Hospital Affiliated to Nanjing Medical University from August 2018 to February 2021 were selected as the research objects,and according to body mass index(BMI),they were divided into 128 cases in obesity group(BMI≥25 kg/m^(2))and 132 cases in non obesity group(BMI<25 kg/m^(2)),and according to the presence or absence of cardiovascular disease,the obesity group patients were divided into no cardiovascular disease group(73 cases)and cardiovascular disease group(55 cases).The clinical data of patients were collected,enzyme-linked immunosorbent assay was used to detect plasma VLDL-C,RBP levels;Pearson method was used to analyze the correlation between plasma VLDL-C,RBP and various clinical data indicators;receiver operating characteristic(ROC)curve was used to analyze plasma VLDL-C,RBP predictive value of cardiovascular disease in obese PCOS patients.Results The levels of BMI,waist hip ratio(WHR),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high sensitivity C-reactive protein(hs-CRP),plasma VLDL-C and RBP in obesity group were higher than those in non obesity group,and the level of high density lipoprotein-cholesterol(HDL-C)was lower than that in non obesity group,the difference were statistically significant(all P<0.05);the levels of plasma VLDL-C and RBP in patients in cardiovascular disease group were higher than those in patients in no cardiovascular disease group,the differences were statistically significant(P<0.05);the plasma VLDL-C and RBP were positively correlated with BMI,WHR,HbA1c,HOMA-IR,TC,LDL-C and hs-CRP,the differences were statistically significant(all P<0.05),and negatively correlated with HDL-C,the

关 键 词：极低密度脂蛋白胆固醇 视黄醇结合蛋白 肥胖型 多囊卵巢综合征 心血管疾病 

分 类 号：R711.75[医药卫生—妇产科学]