前成脂细胞及其临床应用潜能研究进展  

Research progression on preadipocyte and its clinical application potential

作　　者：周晓洁 于湄[1] 田卫东[1] Zhou Xiao-Jie;Yu Mei;Tian Wei-Dong(National Engineering Laboratory for Oral Regenerative Medicine/West China School of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医学院/口腔再生医学国家地方联合工程实验室,成都610041

出　　处：《解放军医学杂志》2022年第2期178-185,共8页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点研发计划(2017YFA0104800);四川省科技计划重点研发项目(2019YFS0312,2019YFS0515)。

摘　　要：脂肪组织与营养平衡和代谢性疾病密切相关,其中脂肪细胞的分化方式将直接影响脂肪组织的健康。前成脂细胞,是脂肪组织中一群能且仅能向成熟脂肪细胞分化的细胞,因其良好的成脂潜能,在再生医学和肥胖相关疾病的治疗中起着重要作用。本综述根据近年来前成脂细胞的相关研究成果,对前成脂细胞定义的不确定性进行了讨论,初步探讨了前成脂细胞的起源及终末分化,归纳总结了常见的前成脂细胞表面标志物,最后对前成脂细胞在软组织修复重建、肥胖相关代谢性疾病,以及肿瘤和伤口愈合方面的临床应用潜能进行了展望。Adipose tissue is inextricably linked to nutritional balance and metabolic diseases,and the way of adipocytes differentiation will directly affect the health of adipose tissue.Preadipocytes are cells that are present at adipose depot and restricted to becoming mature adipocytes specificity.Their favorable differentiation ability to differentiate into healthy mature adipocytes as well as undergo hyperplasia (the expansion of adipose tissue by de novo adipocytes) rather than hypertrophy (the expansion of adipose tissue by increasing the size of already being adipocytes) is crucial for regenerative medicine and obesity-related diseases.Despite much effort has focused on the factors and mechanism about preadipocyte’s adipogenic differentiation,the precise regulatory mechanism is still not completely clear.Based on the related research in recent years,this review discusses the ambiguous definition,the origin and terminal differentiation of preadipocytes in brief,summarizes the surface markers of preadipocytes in detail which include stem cell surface markers (such as CD29,CD34,CD38 and SCA1),perivascular markers (such as PDGFRα and PDGFRβ),ZFP423 (zinc-finger protein 423),Pref-1/DLK1 (preadipocyte factor 1).The deep look at preadipocytes provides new ideas for clinical diagnosis and treatment.The clinical application potential of preadipocytes in the treatment of soft tissue defects,obesity-related metabolic diseases,tumors (breast cancer and prostate cancer),and wound healing is further discussed in this review.

关 键 词：前成脂细胞 表面标志物 成脂分化 临床应用潜能 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]