血清整合素β1、纤维粘连蛋白和层粘连蛋白在子宫内膜异位症中的临床价值  

Clinical value of serum integrin β1,fibronectin and laminin in endometriosis

作　　者：傅萍 FU Ping(Department of Obstetrics and Gynecology,the Obstetrics and Gynecology of Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院妇产科,上海200090

出　　处：《检验医学与临床》2022年第5期634-637,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清整合素β1(ITGb1)、纤维粘连蛋白(FN)和层粘连蛋白(LN)在子宫内膜异位症(EMT)中的临床价值。方法选择2019年1月至2020年12月在该院就诊的EMT患者96例为EMT组,另选择同期体检健康者52例为对照组。采用酶联免疫吸附试验检测各组血清ITGb1、FN和LN水平。比较两组血清ITGb1、FN和LN水平,采用受试者工作特征(ROC)曲线分析血清ITGb1、FN和LN对EMT的诊断效能,分析血清ITGb1、FN和LN水平与痛经严重程度、EMT分期和分型的关系。结果EMT组血清ITGb1、FN和LN水平高于对照组(P<0.05);血清ITGb1、FN和LN 3项联合检测诊断EMT的灵敏度为97.9%,特异度为86.5%,曲线下面积为0.973,均高于各项单独检测(P<0.05);EMT患者血清ITGb1、FN和LN水平随着分期和痛经严重程度的升高而升高(P<0.05)。EMT活动型患者血清ITGb1、FN和LN水平高于非活动型患者(P<0.05)。结论血清ITGb1、FN和LN水平能够反映EMT的严重程度,3项联合检测对EMT具有较好的诊断效能。Objective To investigate the clinical value of serum integrinβ1(ITGb1),fibronectin(FN)and laminin(LN)in endometriosis(EMT).Methods A total of 96 patients with EMT in the hospital from January 2019 to December 2020 were selected as the EMT group,and 52 healthy people who underwent a physical examination in the hospital during the same period were selected as the control group.The serum expression levels of serum ITGb1,FN and LN were determined by enzyme-linked immunosorbent assay in each group.The serum ITGb1,FN and LN levels were compared between the two groups.The diagnostic efficacy of serum ITGb1,FN and LN for EMT was analyzed by receiver operating characteristic(ROC)curve,and the relationship between serum levels of ITGb1,FN,LN and the severity of dysmenorrhea,EMT staging and classification was analyzed.Results The serum ITGb1,FN and LN levels in the EMT group were significantly higher than those in the control group(P<0.05).The serum ITGb1,FN and LN levels had high diagnostic efficiency in the diagnosis of EMT.The sensitivity of the combined detection was 97.9%,the specificity was 86.5%,and the area under the curve was 0.973,which was significantly higher than those of single detection(P<0.05).The serum ITGb1,FN and LN levels in EMT patients increased significantly with the increase of staging and the severity of dysmenorrhea(P<0.05).The serum levels of ITGb1,FN and LN in patients with active EMT were significantly higher than those in inactive patients(P<0.05).Conclusion The serum ITGb1,FN and LN levels can reflect the severity of EMT,and the combined detection of serum ITGb1,FN and LN levels has a high diagnostic efficiency for EMT.

关 键 词：整合素Β1 纤维粘连蛋白 层粘连蛋白 子宫内膜异位症 诊断效能 

分 类 号：R711.71[医药卫生—妇产科学]