妊娠合并亚临床性甲状腺功能减退症患者血清IGF-1、lipocalin-2水平与甲状腺激素和母婴结局的关系  

The correlation of serum IGF-1,lipocalin-2 levels with thyroid hormone and maternal and neonatal outcomes in pregnant women with subclinical hypothyroidism

作　　者：康连风 郭富生 张琼[1] KANG Lianfeng;GUO Fusheng;ZHANG Qiong(Department of Obstetrics,Xinfeng County People′s Hospital,Ganzhou,Jiangxi 341600,China)

机构地区：[1]江西省赣州市信丰县人民医院产科,江西赣州341600

出　　处：《检验医学与临床》2022年第5期638-641,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨妊娠合并亚临床性甲状腺功能减退症(SCH)患者血清胰岛素样生长因子-1(IGF-1)、中性粒细胞明胶酶相关脂质运载蛋白-2(lipocalin-2)水平与甲状腺激素和母婴结局的关系。方法选取2019年8月至2020年7月该院收治的妊娠合并SCH患者74例作为观察组,选取同期体检健康孕妇70例作为对照组。检测两组血清IGF-1、lipocalin-2及甲状腺激素指标[游离三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH)、游离甲状腺素(FT4)]水平。观察并记录对照组、观察组母婴结局情况,根据不同母婴结局将观察组进一步分为母婴不良结局组及母婴正常结局组,比较两组的血清IGF-1、lipocalin-2及甲状腺激素指标水平。分析血清IGF-1、lipocalin-2水平与甲状腺激素指标的相关性。结果观察组血清IGF-1水平低于对照组,lipocalin-2、TSH水平则高于对照组,差异有统计学意义(P<0.05)。观察组的母婴不良结局总发生率高于对照组(P<0.05)。母婴不良结局组血清lipocalin-2、TSH水平高于母婴正常结局组,IGF-1水平低于母婴正常结局组(P<0.05)。Pearson线性相关分析结果显示,IGF-1与TSH呈负相关(r=-0.452,P<0.05),lipocalin-2与TSH呈正相关(r=0.447,P<0.05)。结论妊娠合并SCH患者血清IGF-1、lipocalin-2水平存在异常,其水平变化与甲状腺激素、母婴结局有关,可能有助于指导疾病的诊断和治疗。Objective To investigate the correlation of serum insulin-like growth factor-1(IGF-1),neutrophil gelatinase associated lipid carrier protein-2(lipocalin-2)levels with thyroid hormone and maternal and neonatal outcomes in pregnant women with subclinical hypothyroidism(SCH).Methods From August 2019 to July 2020,a total of 74 pregnant women with SCH who came to the hospital for treatment were selected as the observation group,and 70 healthy pregnant women who came to the hospital for physical examination during the same period were selected as the control group.The levels of thyroid hormone were detected,including free triiodothyronine(FT3),thyroid stimulating hormone(TSH)and free thyronine(FT4),and serum IGF-1 and lipocalin-2 levels were detected.The maternal and neonatal outcomes in two groups were observed and recorded.According to different maternal and neonatal outcomes,the observation group was further divided into maternal and neonatal adverse outcomes group and maternal and neonatal normal outcomes group,serum IGF-1,lipocalin-2 and thyroid hormone levels were compared between the two groups.The correlation between serum IGF-1,lipocalin-2 levels and thyroid hormone indexes were analyzed.Results The level of serum IGF-1 in the observation group was lower than that in the control group,while the levels of lipocalin-2 and TSH were higher than those in the control group,the differences between groups were statistically significant(P<0.05).The incidence of maternal and neonatal adverse outcomes in the observation group was higher than that in the control group(P<0.05).The levels of serum lipocalin-2 and TSH in the maternal and neonatal adverse outcomes group were higher than those in the maternal and neonatal normal outcome group,while the level of IGF-1 was lower than that in the maternal and neonatal normal outcome group(P<0.05).Pearson linear correlation analysis showed that IGF-1 was negatively correlated with TSH(r=-0.452,P<0.05).Lipocalin-2 was positively correlated with TSH(r=0.447,P<0.05).Conclusion The se

关 键 词：妊娠 亚临床性甲状腺功能减退症 胰岛素样生长因子-1 中性粒细胞明胶酶相关脂质运载蛋白-2 甲状腺激素 母婴结局 

分 类 号：R714.256[医药卫生—妇产科学]