阿伦磷酸钠联合鲑鱼降钙素与有氧运动对绝经后妇女骨质疏松症腰椎功能的影响  

Effect of alendronate sodium combined salmon calcitonin and aerobic exercise on lumbar function of postmenopausal women with osteoporosis

作　　者：吴平平 董俊党 王其静 杨宁 WU Pingping;DONG Jundang;WANG Qijing;YANG Ning(Department of Rehabilitation Medicine,Fuding Hospital,Fuding 355200,China)

机构地区：[1]福建省福鼎市医院康复医学科,355200

出　　处：《临床合理用药杂志》2022年第3期40-43,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探究阿伦磷酸钠联合鲑鱼降钙素与有氧运动对绝经后妇女骨质疏松症腰椎功能的影响。方法选取福鼎市医院2017年6月—2018年6月收治的绝经后骨质疏松症患者110例作为研究对象,按随机投掷法分为对照组和研究组,每组55例。对照组采用阿伦磷酸钠治疗;研究组采用阿伦磷酸钠联合鲑鱼降钙素与有氧运动治疗,均治疗6个月。比较2组临床疗效,治疗前后关节疼痛情况、腰椎功能、平衡功能、骨密度(股骨颈密度、腰椎骨密度、双髋骨密度)、血清骨钙素、血清骨代谢指标[血清胰岛素样生长因子1(IGF-1)、肿瘤坏死因子α(TNF-α)],并观察2组不良反应发生情况。结果治疗后研究组患者总有效率为92.73%,高于对照组的74.55%(χ^(2)=6.643,P=0.010)。治疗后2组数字疼痛评分(NRS)低于治疗前,JOA下腰功能量表(JOA)评分、Berg平衡量表(BBS)高于治疗前,且研究组NRS评分低于对照组,JOA评分、BBS高于对照组(P<0.05)。治疗后2组股骨颈密度,腰椎骨密度高于治疗前,骨钙素低于治疗前,研究组双髋骨密度高于治疗前,且研究组股骨颈密度、腰椎骨密度、双髋骨密度高于对照组,骨钙素低于对照组(P<0.05)。治疗后2组IGF-1高于治疗前,TNF-α低于治疗前,且研究组IGF-1高于对照组,TNF-α低于对照组(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论阿伦磷酸钠联合鲑鱼降钙素与有氧运动在改善绝经后妇女骨质疏松症患者病情及腰椎功能方面有积极作用,有利于改善患者腰椎功能,提升骨密度含量,且安全性较高。Objective To investigate the effect of alendronate sodium combined salmon calcitonin and aerobic exercise on lumbar function of postmenopausal women with osteoporosis.Methods One hundred and ten patients with postmenopausal osteoporosis admitted to Fuding Hospital from June 2017 to June 2018 were selected as the research subjects.They were randomly divided into control group and study group by throwing method,55 cases in each group.The control group was treated with alendronate sodium,and the study group was treated with alendronate sodium combined salmon calcitonin and aerobic exercise.Clinical effect,the pain of articulation,the function of lumbar vertebra,bone density(femoral neck density,lumbar spine bone density,hip bone density),osteocalcin,the indexes of bone metabolism[insulin like growth factor-1(IGF-1),tumor necrosis factor-α(TNF-α)]were compared between two groups before and after treatment and the incidence of adverse reactions were observed.Results The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the numerical pain score(NRS)of two groups was lower than that before treatment,and the JOA lower back function score(JOA)and Berg balance function score(BBS)were higher than those before treatment,and NRS of study group was lower than that of control group,and JOA and BBS were higher than those of control Group(P<0.05).After treatment,femoral neck density,lumbar spine bone density of the two groups were higher than those before treatment,and osteocalcin of the two groups was lower than that before treatment,and hip bone density of study group was higher than that before treatment.After treatment,femoral neck density,lumbar spine bone density,hip bone density of the study group were higher than those of the control group,and the serum osteocalcin of study group was lower than that of control group(P<0.05).After treatment,IGF-1 of two groups was higher than that before treatment,and TNF-α of two group was lower than that before treatment;after tr

关 键 词：骨质疏松症 阿伦磷酸钠 有氧运动 腰椎功能 

分 类 号：R580[医药卫生—内分泌]