纳曲酮治疗儿童炎症性肠病的研究进展  

Research progress on naltrexone in the treatment of children with inflammatory bowel disease

作　　者：曹培同 吴捷 Cao Peitong;Wu Jie(Department of Pediatric Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Gastroenterology,Beijing Children′s Hospital,Capital Medical University,Beijing 100044,China)

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,沈阳110004 [2]首都医科大学附属北京儿童医院消化内科,100044

出　　处：《中国小儿急救医学》2022年第1期71-74,共4页Chinese Pediatric Emergency Medicine

摘　　要：炎症性肠病是指原因不明的一组非特异性慢性胃肠道炎症性疾病,包括溃疡性结肠炎、克罗恩病和未定型结肠炎。近年来,儿童炎症性肠病发病率有上升趋势,严重影响着患儿的生长发育和生活质量。研究表明阿片受体拮抗剂纳曲酮能够逆转炎症性肠病中的炎症活动并促进肠上皮细胞修复。本文就纳曲酮在炎症性肠病治疗中的应用进展进行综述,旨在对纳曲酮治疗儿童炎症性肠病的有效性及安全性进行进一步探讨。Inflammatory bowel disease refers to a group of non-specific chronic gastrointestinal inflammatory diseases of unknown causes,including ulcerative colitis,Crohn′s disease and indeterminate colitis.Recently,the incidence of inflammatory bowel disease in children has increased,which seriously affects the growth and development of children and the quality of life.Studies have shown that the opioid receptor antagonist naltrexone can reverse the inflammatory activity in inflammatory bowel disease and promote cell repair.This review summarized the research of application of naltrexone in the treatment of inflammatory bowel disease,aiming to further explore the effectiveness and safety of naltrexone in the treatment of inflammatory bowel disease in children.

关 键 词：炎症性肠病 纳曲酮 儿童 治疗 

分 类 号：R725.7[医药卫生—儿科]